Tremor, Nystagmus, And Duodenal Ulcer

Clinical Features

Neuhauser et al. (1976) described tremor, nystagmus, and duodenal ulcer in multiple persons in a kindred. Essential tremor developed in 12 of 17 affected members. Alcohol controlled the tremor temporarily. Severely affected members became alcoholics. The most severely affected persons showed cerebellar signs. Nystagmus occurred often in the absence of tremor and was usually congenital. Duodenal ulcer appeared to be a pleiotropic effect. It sometimes preceded onset of tremor.

Inheritance

The transmission pattern of tremor, nystagums, and duodenal ulcer in the family reported by Neuhauser et al. (1976) was consistent with autosomal dominant inheritance.