Generalized Glucocorticoid Resistance Syndrome
Watchlist
Retrieved
2021-01-23
Source
Trials
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Genes
NR3C1,
KMT2A,
ABCB1,
FKBP5,
PIK3CB,
HDAC2,
GRP,
PIK3CG,
PIK3CD,
PIK3CA,
IL6,
IL7,
TBC1D9,
MCL1,
FKBP4,
MIF,
BCL2L11,
BCL2,
TNF,
MIR128-2,
MIR142,
MIR221,
POMC,
IKZF1,
SOAT1,
SRC,
SYT1,
HDAC9,
TGFB1,
SRSF9
NR3C1,
KMT2A,
ABCB1,
FKBP5,
PIK3CB,
HDAC2,
GRP,
PIK3CG,
PIK3CD,
PIK3CA,
IL6,
IL7,
TBC1D9,
MCL1,
FKBP4,
MIF,
BCL2L11,
BCL2,
TNF,
MIR128-2,
MIR142,
MIR221,
POMC,
IKZF1,
SOAT1,
SRC,
SYT1,
HDAC9,
TGFB1,
SRSF9,
TOP2A,
ARID1A,
USP9X,
UMOD,
NR2C2,
ACAD8,
NCOA2,
MYBBP1A,
USP17L30,
USP17L29,
USP17L28,
USP17L27,
USP17L26,
USP17L25,
USP17L24,
MIR182,
MIR17,
USP17L9P,
USP17L2,
NLRP3,
TBL1XR1,
WNK1,
GORASP1,
CRLF2,
GAS5,
KRT20,
PELP1,
S100A9,
CIB2,
SMARCA1,
ADCY9,
S100A8,
CDKN1C,
FOS,
ENO2,
DUSP1,
DPT,
CYP3A5,
CYP2B6,
CYP3A7,
CRP,
CDK6,
MTOR,
CDK4,
MS4A1,
RUNX1,
CASP1,
BDNF,
ANXA2,
AKT2,
AKT1,
FOSB,
GLI2,
RELA,
JUNB,
MAP2K7,
MAPK8,
JAG1,
MUC1,
MMP9,
NR3C2,
LCK,
JUND,
JUN,
MSH6,
IL7R,
IL4,
IL2,
IL1B,
IGF1,
IFNG,
HSP90AB1,
HIF1A,
LINC02605
Drugs
—
Registered!
A rare, adrenogenital syndrome characterized by generalized, partial tissue insensitivity to glucocorticoids leading to variable phenotype, including asymptomatic individuals with only biochemical alterations or patients with ambiguous genitalia at birth in females, hypertension, acne, hirsutism, precocious puberty, male-pattern hair loss, anxiety and depression in both sexes, menstrual irregularities in women, and oligospermia in men.