Traditional Serrated Adenoma

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Retrieved

2021-01-18

Source

Wikipedia

Trials

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Genes

KRAS, BRAF, TRIM21, CTNNB1, CALR, EPHB2, RSPO2, RSPO1, RNF43, MGMT, PTCH1, TP53, TGFBR2, HDAC2, APC, PTPRK, RSPO3, SMN2, ABCG2, SP1, PTPRD, SMN1, PRDX2, TGFB1, TLE1, OPN1LW, VEGFA, TRPV1, H3-4, STC1

KRAS, BRAF, TRIM21, CTNNB1, CALR, EPHB2, RSPO2, RSPO1, RNF43, MGMT, PTCH1, TP53, TGFBR2, HDAC2, APC, PTPRK, RSPO3, SMN2, ABCG2, SP1, PTPRD, SMN1, PRDX2, TGFB1, TLE1, OPN1LW, VEGFA, TRPV1, H3-4, STC1, ACTB, GDF15, HDAC9, MIR106B, TRPM8, PCBP4, BEX4, PAG1, HDAC7, BBC3, RPL13A, CLUH, GPR182, SEPTIN9, LEFTY1, TUBA1B, BCL2L11, PIEZO1, PTGS1, ABCB1, KLK6, MAPK8, HDAC1, GRIA1, GNAS, GAPDH, MTOR, FOXO1, EZH2, ERBB2, EIF4E, EGFR, E2F1, CREBBP, CLU, CDKN1A, ATP2A3, AQP1, ADH1C, HIF1A, ICAM1, EIF3E, MUC6, PIK3CA, ADH1B, NRAS, NOS2, NOS1, NFE2L2, MMUT, MUC5AC, IRAK1, MUC2, COX1, MSH2, MLH1, SMAD2, LHCGR, KRT7, POTEF

Drugs

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Traditional serrated adenomas (TSA) is a premalignant type of polyp found in the colon, often in the distal colon (sigmoid, rectum). TSAs are a type of serrated polyp, and may occur sporadically or as a part of serrated polyposis syndrome. TSAs are relatively rare, accounting for <1% of all colon polyps. Usually, TSAs are found in the distal colon and are usually less than 10 mm in size.

Histopathology

Traditional serrated adenomas are characterized by ectopic crytps, pseudostratification, and a villous pattern with stretched nuclei.

Epidemiology

Usually found in individuals over the age of 50 years, TSAs affect men and women equally. The overall prevalence of traditional serrated adenomas is less than 1% of the general population.