Amyotrophic Lateral Sclerosis 7

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Retrieved
2019-09-22
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For a phenotypic description and a discussion of genetic heterogeneity of amyotrophic lateral sclerosis (ALS), see ALS1 (105400).

Mapping

Sapp et al. (2003) performed a genetic linkage screen in 16 U.S. pedigrees with familial ALS and no evidence for mutations in the SOD1 gene (147450). In 1 of the 16 families, they identified a novel ALS locus, designated ALS7, spanning a 6.25-cM (1-Mb) region on chromosome 20p. A multipoint lod score calculated for this family had a peak value of 3.46 at D20S103. In another family, Sapp et al. (2003) identified a novel ALS locus on chromosome 16 (ALS6; 608030).