Acrocephalopolysyndactyly Type Iii

This designation may be appropriate for the malformation syndrome described by Sakati et al. (1971) in a single male. The calvaria was large and the face disproportionately small. All cranial sutures were fused. The ears were dysplastic and low-set. Maxillary hypoplasia, dental crowding, prognathism and short neck with low hairline were features. A sixth digit had been removed from the right hand. The feet were adducted and showed polysyndactyly with 7 toes on the right and 6 toes on the left. The tibias were hypoplastic and the fibulas were deformed and displaced. The chromosomes were normal. Advanced parental age supported new dominant mutation as the cause. No other cases have, it seems, been reported.