Diffuse Large B-Cell Lymphoma
Watchlist
Retrieved
2022-04-26
Source
Trials
—
Genes
EZH2,
MYD88,
CARD11,
PIK3CD,
CD79B,
CD79A,
PRDM1,
CD274,
PIK3CG,
MYC,
CDKN2A,
PIK3CA,
ALK,
PIK3CB,
ABCB1,
BCL2,
MALT1,
CREBBP,
EP300,
JAK2,
FAS,
FOXO1,
GLI1,
B2M,
KMT2D,
ABCG2,
CDK2,
RPS6KB1,
GNA13,
STAT6
EZH2,
MYD88,
CARD11,
PIK3CD,
CD79B,
CD79A,
PRDM1,
CD274,
PIK3CG,
MYC,
CDKN2A,
PIK3CA,
ALK,
PIK3CB,
ABCB1,
BCL2,
MALT1,
CREBBP,
EP300,
JAK2,
FAS,
FOXO1,
GLI1,
B2M,
KMT2D,
ABCG2,
CDK2,
RPS6KB1,
GNA13,
STAT6,
CDK1,
IRF8,
FBXO11,
IKZF1,
NOTCH2,
SKP2,
CLTC,
PDPK1,
PRDM11,
RANGAP1,
NECTIN2,
SOD2,
SGK1,
SOD3,
NOM1,
PRDX3,
SPEN,
CAT,
TRAF5,
TP53,
TXNIP,
BCAS2,
SEC31A,
CCDC86,
PRDX4,
IMMP2L,
SMURF2,
HLA-B,
CD86,
SMUG1,
PWWP3A,
TNFRSF8,
ARAP3,
MIR34A,
GBA,
NCOA5,
BCL10,
AICDA,
DDIT3,
CDC42BPB,
FOXP1,
RTEL1,
IGH,
MIR155,
NPR2,
NOS2,
TNF,
KRT20,
TNPO2,
STAT3,
MIR21,
LMO2,
NOS1,
AKT1,
SYK,
CCND1,
KALRN,
CXCR4,
MCL1,
MME,
IGHV3-69-1,
PVT1,
MMEL1,
MGMT,
IL10,
IRF4,
BTK,
DLEU1,
ATM,
ABCB6,
BCL6,
CD19,
MS4A1,
FCGR3A,
LOC102723407,
H3P10,
PAX5,
PRKAR1A,
PTEN,
IL6,
LOC102724971,
SPG7,
CXADR,
ARR3,
FOXP3,
CASR,
PDLIM7,
TRIM13,
NR1I3,
BIRC3,
NFKB1,
CXADRP1,
IL2,
CCND2,
CD40,
SOAT1,
TCL1A,
MEF2B,
REL,
MET,
GSTP1,
MCTS1,
PDE4B,
PDCD1,
SLC16A1,
CDKN1B,
PDCD1LG2,
PIM1,
IGHV3OR16-7,
HDAC9,
IL4,
HDAC6,
SDC1,
DNER,
TBC1D9,
MCAT,
MDM2,
ALB,
CDKN2B,
CDR3,
TNFAIP3,
TCL1B,
HTC2,
CMA1,
MTHFR,
CCND3,
ZC3H12D,
DAPK1,
WEE1,
VEGFA,
TP63,
CTNNB1,
MIR17HG,
GCSAM,
CD44,
CD38,
PLK1,
GSTT1,
PTPN6,
GSTM1,
FHIT,
MAPK3,
ERCC2,
MAPK1,
MTOR,
CDK4,
BCL3,
SOCS1,
SMAD1,
CASP3,
LTA,
XBP1,
CD22,
TNFSF13B,
LAIR1,
KMT2B,
TET2,
BCL2A1,
BACH2,
IFNG,
CD163,
S1PR2,
LIG4,
IL21,
MIR15A,
HSP90AA1,
NFKB2,
PARP9,
CDK9,
KRAS,
UHMK1,
MTA3,
POU2F2,
IL21R,
PDE4A,
MLH1,
JAK1,
ACKR3,
MKI67,
HIF1A,
KMT2A,
MIR155HG,
MTX1,
MUC1,
NEK2,
NRAS,
HLA-DRB1,
KLHL6,
HLA-C,
NCAM1,
LGALS1,
CDKN1C,
CXCL12,
SERPINA9,
BCR,
SLC22A2,
ARID1A,
LOC390714,
CUX1,
SOX11,
CIB1,
SPIB,
SPN,
SPP1,
MRPL28,
CR2,
CASP1,
TPX2,
CCK,
TRBV20OR9-2,
CHEK2,
FOXM1,
MIR224,
SUB1,
CD37,
TXN,
SIRT1,
CD58,
H3P9,
PTPN1,
EPHB2,
NXT1,
FCGR2A,
PTPRC,
LOC105379528,
SART3,
RHOH,
CES2,
PARP1,
CCL2,
CCL5,
APC,
MSH3,
WRN,
MIB1,
LPP,
EZR,
VIM,
MTAP,
SLC16A4,
UVRAG,
DCTN6,
SLC16A3,
XPO1,
MBTPS1,
XRCC1,
PRMT5,
MAL,
EBI3,
CFLAR,
EFS,
UCHL1,
MAD2L1,
LYN,
EXOC2,
MDM4,
SOCS3,
ZNRD2,
HIP1R,
ZAP70,
MTA1,
DIABLO,
PRKCB,
TYMS,
HPGDS,
SLC19A1,
PMEL,
BRD4,
CRBN,
SCT,
IBTK,
RPE65,
SND1,
RFC1,
PLCG2,
MXI1,
IRAK4,
PTPRO,
TMED7,
POLD1,
POU2AF1,
PTPN2,
IGK,
IL22,
PSMD9,
PCNA,
SLPI,
ABL2,
SMO,
TRAF6,
TRAF3,
NR2C2,
TP73,
CKAP4,
NFATC1,
NFE2L2,
PSIP1,
NME1,
ZEB1,
MAP3K7,
KDM6B,
TLR9,
STAT1,
ACSBG1,
NOTCH1,
ROR1,
OAS3,
SPI1,
SLC7A4,
SMARCA4,
LGALS3,
GRN,
FKBP4,
CCNE1,
CASP9,
FLT1,
MIR497,
GABPA,
GAPDH,
C1QA,
ANTXR2,
GNA12,
GOT2,
TNFRSF13C,
GPX4,
BTG1,
HSPA4,
GTF2H4,
GZMB,
H2AX,
BRCA1,
MTDH,
HK2,
BPI,
HLA-DQB1,
HMGB1,
HAVCR2,
TMED7-TICAM2,
BDNF,
NR4A1,
FCGR3B,
FASN,
ETS1,
CD28,
CRP,
CSF2,
MIR146A,
MIRLET7B,
MALAT1,
MIR17,
MIR195,
TICAM2,
DNMT1,
DNMT3A,
MIR214,
E2F1,
MIR223,
EIF4B,
CDKN1A,
EIF4E,
MIR23A,
EIF4EBP1,
CDH1,
MIR31,
CD70,
ERCC5,
BTLA,
DTX3L,
ESR2,
CD36,
ETFA,
OPN1SW,
MIR142,
ASCC2,
PPP1R2C,
IL2RA,
IL4R,
CXCL8,
IL10RA,
ID3,
IL17A,
VTCN1,
BIRC5,
IRF1,
ISG20,
RAPH1,
ITGAX,
ITPR2,
H3P23,
H3P42,
ADA,
KDR,
ACVRL1,
GAS5,
LAG3,
LAMC2,
LBR,
ACTB,
ATP7A,
TNFRSF9,
ATR,
BCL2L2-PABPN1,
BCL2L2,
IFI27,
HDAC4,
IL24,
WIF1,
RASSF1,
MIR221,
CORO1A,
GLMN,
IL1RAPL1,
MIR222,
CCR2,
PIM2,
BCL2L10,
METAP2,
H3P47,
TNIP1,
COPS5,
SH3BP5,
MIR25,
MIR27A,
MIR27B,
MELK,
MIR28,
MIR22,
VSIG4,
CD300A,
SNHG16,
NCR2,
RCOR1,
AIM2,
PASK,
MIR145,
RAD50,
LINC01672,
MIR150,
MIR16-1,
SPART,
KDM1A,
MIR30A,
MAP4K4,
MIR1234,
MIR197,
MLXIP,
BCL2L11,
MIR200C,
SYCE1L,
MIR210,
PHB2,
HOTAIR,
MIR29C,
NAPSA,
POTEF,
MIR33A,
MIR494,
RACK1,
RBCK1,
NCOR2,
AHSA1,
CCT4,
MIR504,
CXCL13,
SNHG14,
MIR4638,
POU5F1P3,
TP53COR1,
ANP32B,
YAP1,
BATF,
POU5F1P4,
PANDAR,
MIR144,
USP34,
HULC,
D2HGDH,
CIB2,
MAD2L2,
LUNAR1,
MIR146B,
NCOR1,
KEAP1,
BAG3,
HSPH1,
MASP2,
WARS2,
MNS16A,
MIR99A,
MTCO2P12,
MIR135B,
LRP1-AS,
NPM3,
MTSS1,
SMAD5-AS1,
BCLAF1,
MIR148B,
CXCR6,
MIR328,
MIR431,
PRDX6,
MIR323B,
MIR451A,
MIR511,
WTAP,
LINC00273,
NEAT1,
MDN1,
KDM2B,
MAP3K20,
BCL11A,
IL17D,
FCRLA,
PRKAG3,
RIPK4,
GLIS2,
MIR127,
MIXL1,
FSD1L,
ARHGAP24,
PARP14,
LY6K,
DOHH,
ORAI1,
IL23A,
CHRDL1,
UCHL5,
NAPRT,
C1RL,
MZB1,
CGB5,
FOXP2,
CGB8,
PRRT2,
LEF1,
CARD16,
RMDN1,
ASCC1,
RASGRP4,
MSI2,
FCRL4,
DOCK8,
TRPM4,
EAF2,
KLHL1,
PCDH10,
GRAP2,
SLC5A7,
NDRG2,
NSD1,
GMCL1,
PCBP4,
GORASP1,
P2RY12,
WNK1,
MYDGF,
LMO3,
FSD1,
PAG1,
MAP1LC3B,
MORC4,
CCAR1,
RNF34,
NLRP2,
SYBU,
MEG3,
LAPTM4B,
FBXW7,
RMDN3,
TUG1,
ELL3,
MPIG6B,
DEFB126,
PGPEP1,
IL31RA,
F11R,
SLCO6A1,
SIRT3,
CNRIP1,
FOXK1,
CNOT6L,
RNF19A,
SSBP2,
IL27,
AMACR,
PATZ1,
NUTM1,
SLAMF7,
LOC283177,
PRAME,
LYPD5,
FIRRE,
ILDR1,
TES,
EIF4E3,
DICER1,
TSPAN33,
ZACN,
GSTK1,
SLC27A1,
CRTC1,
TMEM189,
TMEM189-UBE2V1,
NEDD4L,
SIK2,
MIRLET7G,
MIR10A,
MIR125A,
POLDIP2,
PHGDH,
PPARGC1B,
COMMD1,
ADGRE2,
CD109,
PASD1,
HT,
VPREB3,
BLNK,
IL34,
LGALS13,
MYLIP,
PYCARD,
APCDD1,
LYPD4,
LGALS16,
SETD2,
IGHV3-23,
CKAP2,
IGHV3-52,
RMDN2,
IGHV4-34,
EML4,
SGSM3,
NKX6-3,
UBR1,
CRTC2,
AGO2,
KLHDC8B,
MORC1,
MARCHF8,
RASGEF1A,
HAVCR1,
CXCL16,
NAT2,
KL,
GCLC,
FLI1,
FN1,
FOS,
FOSB,
KDSR,
XRCC6,
GATA2,
GATA3,
GEM,
GLI2,
LIF,
GPI,
XCR1,
MKNK2,
GPX1,
NR3C1,
GSTA1,
GUCA1B,
HDAC2,
HELLS,
FBP1,
FABP7,
ETV6,
ETV5,
ATN1,
DUSP4,
DVL3,
S1PR1,
EFNA5,
EFNB2,
EGF,
EGR3,
EIF4A1,
EIF4A2,
ELAVL2,
ELF3,
ENO2,
EPHA4,
EPHX1,
EPO,
ERG,
ERN1,
ESR1,
HGF,
HIC1,
HLA-DQA1,
IL9,
IL13,
IDO1,
CXCL10,
INPP5D,
IRAK1,
IRF2,
ISL1,
ITGAM,
ITPR1,
ITPR3,
JAK3,
JUN,
JUNB,
JUND,
KIF2A,
KIR3DL1,
LAMP1,
LCK,
LEP,
IL10RB,
IL1B,
HLA-G,
IL1A,
HLX,
HMMR,
HMOX1,
HNMT,
HNRNPK,
TLX1,
HSPA8,
MRPL58,
IDH1,
IDH2,
IFNA1,
IFNA13,
IFNB1,
IGF1,
IGHA1,
IGHM,
JCHAIN,
IGL,
IKBKB,
DPP4,
DOCK2,
DNMT3B,
BLK,
BMI1,
BMP6,
BRAF,
BRCA2,
BUB1B,
BYSL,
TSPO,
SERPING1,
CACNA1C,
CALD1,
CALR,
CASP8,
RUNX3,
CCNH,
CCNT1,
CD247,
CD5,
CD14,
CD27,
CXCR5,
BIK,
CD59,
BGN,
ABO,
ADAM10,
AHR,
ALDH1A1,
AMCN,
AMPD1,
ANXA5,
APAF1,
XIAP,
APP,
APRT,
RHOA,
ARNT,
STS,
ATF3,
BAX,
BCL2L1,
BCL7A,
NBEAP1,
CD47,
CD63,
NQO1,
CCR8,
CNC2,
CNP,
COL3A1,
CRK,
CRY1,
MAPK14,
CSE1L,
CSF1R,
CSF3,
CSNK2B,
CTLA4,
CX3CR1,
CYBA,
CYP1A1,
CYP17A1,
CYP24A1,
DAP,
DAXX,
DCK,
ABCC2,
CCR7,
CD68,
CCR1,
CD74,
CD81,
ADGRE5,
CDC20,
CDC25C,
CDH11,
CDH13,
CDK3,
CDK5,
CDK6,
CDS1,
CEBPA,
CGA,
CGB3,
CHEK1,
FOXN3,
CHGB,
CHM,
CLU,
LEPR,
LMNA,
SLIT2,
UBE2V1,
TNFRSF1B,
TOP1,
TOP2A,
TP53BP1,
TP53BP2,
TPM3,
TPT1,
UBA52,
UBE2N,
UCN,
LMNB1,
UGCG,
UMOD,
VAV1,
WARS1,
YY1,
ZNF134,
ZBTB17,
PRDM2,
BTG2,
TMSB4X,
TLR1,
TLE1,
NKX2-1,
SPARC,
SPRR1A,
SRM,
STAT5A,
STAT5B,
STIM1,
SYN2,
SYT1,
TAP2,
TAT,
TCF4,
TCF7,
TRA,
TRB,
TRG,
TFF3,
TGFB1,
TGFBR1,
THOP1,
BAG6,
AIMP2,
ARHGEF5,
TNFRSF14,
FADD,
TNFRSF10B,
HDAC3,
CDK5R1,
PER3,
PER2,
ARHGEF7,
SPHK1,
TIMELESS,
MBD2,
BTRC,
P4HA2,
NOL3,
MAP3K14,
AIP,
PIAS2,
USP14,
CD83,
RPL23,
TNFRSF6B,
TNFSF10,
NR4A3,
TNFSF13,
MLLT10,
HMGA2,
CLLS2,
USP11,
USP9X,
SMC1A,
PICALM,
CDC7,
SPOP,
NR0B2,
CUL4B,
OGT,
CAMK1,
MKNK1,
RFXANK,
NCOA1,
EIF4G3,
EED,
RIPK1,
SOX2,
SNAP25,
SLC8A1,
NBN,
NEDD8,
NFATC2,
NFE2L1,
NGF,
NODAL,
NOTCH3,
NPM1,
NRF1,
NT5E,
NTRK1,
P2RY1,
SERPINB2,
PCYT1A,
PDK1,
PECAM1,
PHB,
PLAGL1,
PLG,
PLOD2,
NCL,
MTRR,
POLA1,
MTR,
LPL,
LRMP,
SH2D1A,
MXD1,
SMAD5,
MAP4,
MBP,
MC1R,
BORCS8-MEF2B,
MFAP1,
CIITA,
CD99,
CXCL9,
FOXO4,
ABCC1,
MSH2,
MSN,
MST1R,
COX2,
PMAIP1,
POU5F1,
SIAH1,
RDX,
RELB,
RGS1,
RNASEL,
BRD2,
RPS6,
RPS6KA1,
RPS6KA2,
RPS6KA3,
RPS20,
RREB1,
S100A8,
CCL3,
CCL4,
CCL13,
CCL18,
CCL22,
SELL,
SELPLG,
SET,
RELA,
OPN1LW,
PPA1,
RBL1,
PTPA,
PPP2R5E,
PRKAA2,
PRKCA,
MAPK11,
MAP2K7,
LGMN,
PSMB5,
PSMB9,
PTH,
PTGS2,
PTMS,
PTPN13,
PTPRD,
PTPRJ,
RAD1,
RAD23B,
RAD51,
RARA,
H3P40
Drugs
3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione hydrochloride,
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,
Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus
3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione hydrochloride,
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,
Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus,
Autologous CD4+ and CD8+ T cells expressing a CD19-specific chimeric antigen receptor,
Autologous Epstein-Barr virus specific T cells derived from peripheral blood mononuclear cells, expanded ex vivo-,
Autologous engineered anti -CD19 Chimeric Antigen Receptor (CAR +) T -cells
(
KYMRIAH
),
Axicabtagene ciloleucel
(
YESCARTA
),
Brentuximab vedotin
(
ADCETRIS
),
Enzastaurin hydrochloride,
Everolimus
(
AFINITOR,
VOTUBIA
),
Humanised Fc engineered monoclonal antibody against CD19,
Humanised anti-CD37 monoclonal antibody conjugated to maytansinoid DM1,
Ibrutinib
(
IMBRUVICA
),
Iodine (131I) tositumomab,
Lenalidomide
(
LENALIDOMIDE ACCORD,
REVLIMID
),
Mocetinostat,
Obinutuzumab
(
GAZYVA,
GAZYVARO
),
Pixantrone dimaleate
(
PIXUVRI
),
Polatuzumab vedotin
(
POLIVY
),
Pralatrexate
(
FOLOTYN
),
Recombinant histidine-tagged idiotype immunoglobulin Fab fragment of clonal B-cell receptors,
Rituximab
(
BLITZIMA,
MABTHERA,
TRUXIMA,
RITEMVIA,
RITUXAN,
RITUZENA,
RIXATHON,
RIXIMYO,
Ruxience
),
Selinexor
(
XPOVIO
),
Tazemetostat
(
TAZVERIK
),
Valproic acid, sodium,
Venetoclax
(
VENCLEXTA,
VENCLYXTO
),
haematopoietic stem cells and blood progenitors umbilical cord-derived expanded with (1R, 4R)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine dihydrobromide dihydrate
Registered!
Diffuse large B-cell lymphoma (DLBCL), a form of non-Hodgkin lymphoma, is the most common blood cancer. Lymphomas occur when cells of the immune system, known as B lymphocytes, grow and multiply uncontrollably. DLBCL occurs mostly in adults and is a fast-growing (aggressive) lymphoma. It can start in the lymph nodes or outside of the lymphatic system in the gastrointestinal tract, testes, thyroid, skin, breast, bone, or brain. Often, the first sign of DLBCL is a painless rapid swelling in the neck, armpit, abdomen, or groin caused by enlarged lymph nodes. For some people, the swelling may be painful. Other symptoms include night sweats, unexplained fevers, and weight loss.
Treatment may differ depending on the location of the tumor and the subtype of lymphoma. For those who have advanced DCBCL and have not been treated previously, a combination of chemotherapy and the monoclonal antibody rituximab (Rituxan) (R-CHOP) may be tried.. In addition, as of October 2017, axicabtagene ciloleucel (brand name: Yescarta), a type of gene therapy, has been approved by the United States FDA to treat DCBCL that is not responding to at least two treatment attempts or has returned after being treated before. A stem cell transplant may also be an option if DLBCL returns or relapses.
Treatment may differ depending on the location of the tumor and the subtype of lymphoma. For those who have advanced DCBCL and have not been treated previously, a combination of chemotherapy and the monoclonal antibody rituximab (Rituxan) (R-CHOP) may be tried.. In addition, as of October 2017, axicabtagene ciloleucel (brand name: Yescarta), a type of gene therapy, has been approved by the United States FDA to treat DCBCL that is not responding to at least two treatment attempts or has returned after being treated before. A stem cell transplant may also be an option if DLBCL returns or relapses.