Adult T-Cell Leukemia/lymphoma
Watchlist
Retrieved
2021-01-23
Source
Trials
—
Genes
IRF4,
IL2,
CCR4,
FOXP3,
IFNA1,
IL10,
IL4,
STAT3,
TERF2,
TLX1,
IFNG,
BIRC5,
FYN,
PRKCB,
PLCG1,
BMP6,
IKZF2,
GATA3,
CTLA4,
CARD11,
VAV1,
HNRNPA2B1,
CCR7,
CSNK1A1,
CSNK2A1,
CSNK2B,
IFNA2,
TP73,
GPR183,
CD28
IRF4,
IL2,
CCR4,
FOXP3,
IFNA1,
IL10,
IL4,
STAT3,
TERF2,
TLX1,
IFNG,
BIRC5,
FYN,
PRKCB,
PLCG1,
BMP6,
IKZF2,
GATA3,
CTLA4,
CARD11,
VAV1,
HNRNPA2B1,
CCR7,
CSNK1A1,
CSNK2A1,
CSNK2B,
IFNA2,
TP73,
GPR183,
CD28,
ICOS,
CD86,
CD80,
TRBV20OR9-2,
CNTN2,
PTHLH,
HBZ,
ERVK-32,
THBS1,
ATF7IP,
TP53,
CDKN2A,
ISG20,
IL2RA,
CADM1,
TAL1,
NOTCH1,
ERVK-20,
ERVW-1,
FAS,
ICAM1,
ATN1,
H3P10,
SERPINH1,
CD274,
TXN,
ERVK-6,
TNFRSF8,
ERVK-18,
F9,
HLA-A,
H3P13,
BCL2,
CDKN2D,
REG1A,
IL23A,
TCL1A,
TCL1B,
APRT,
MFAP1,
IL1B,
CREBBP,
STAT1,
EZH2,
CDKN2B,
TGFB1,
IFNA13,
IL6,
IL1A,
BCL11B,
GORASP1,
WNK1,
JUN,
JUND,
IL15,
FOS,
CDKN1A,
MVP,
SOAT1,
RELA,
SYT1,
PTH,
PTPA,
PIK3CG,
NDRG2,
PIK3CD,
PIK3CB,
PIK3CA,
CREB1,
MYC,
GZMM,
H3P9,
HSP90AA1,
LCK,
IL13,
NXT1,
TPPP,
SUB1,
ITGAL,
ITGB2,
JAK3,
MRPL28,
MCL1,
TNFSF10,
MSH3,
MYB,
TNFSF11,
VCAM1,
TNF,
PTEN,
RAD51,
CDKN1B,
B2M,
CDK2,
FOSL2,
AKT1,
TRBV16,
TRBV7-9,
TRBC1,
CD40LG,
PTPRA,
KRT20,
CD58,
PSMD10,
S100A4,
PSMD9,
TMED5,
TMED7,
SCLY,
SAI1,
RHOA,
ATM,
FUT4,
CCL3,
MTAP,
MDM2,
MET,
POLD4,
AICDA,
MMP9,
MSH2,
CRP,
POLE4,
CD52,
NCAM1,
NFKB1,
NOS1,
NOS2,
FBXW7,
ABCB1,
TET2,
SIRT1,
CCL22,
LRP1,
SELL,
TNFRSF4,
PRMT5,
CASP3,
PATJ,
BCAP31,
XPO1,
DNALI1,
TOX,
CDR3,
GOSR1,
SOCS1,
TBPL1,
GSTO1,
NOG,
TNFRSF10A,
MAGI1,
CFLAR,
CAT,
CIB1,
ZNRD2,
STAT5B,
CCND1,
SMARCA4,
CHP1,
TMED2,
CD34,
DCTN6,
STAT5A,
SYK,
BCR,
MS4A1,
CD9,
TAL2,
TARS1,
ZEB1,
TRB,
TERT,
CTAG1B,
PDCD1,
LOXL2,
RPSA,
JUNB,
DPP4,
NRSN1,
CNKSR3,
IL9,
CTAG1A,
IL27,
TICAM2,
ETS1,
IFI27,
TMED7-TICAM2,
FCGRT,
HRES1,
HLA-DRB1,
HLA-B,
FOSB,
HGF,
MSH6,
CCR10,
H3P23,
H3P24,
H3P19,
H3P5,
KRT7,
IFNL3,
ALK,
CTNNB1,
ATL2,
LMO2,
LORICRIN,
LGALS9,
NOX5,
LBX1,
CTCF,
MIR1193,
CXCR6,
TXNIP,
CDKN2B-AS1,
PDLIM5,
MIR3662,
AHSA1,
XIAP,
BATF,
RPL17-C18orf32,
RTN4,
POTEF,
AZI2,
H3P37,
JPX,
PIM3,
MIR31,
MIR28,
CCR9,
CCL27,
BCL6,
MIR212,
DSTN,
BCL2L1,
MAP4K5,
AKAP13,
ATG7,
STAMBPL1,
KAT5,
SPATA2,
LPAR2,
PRDM16,
APOBEC3G,
UBL5,
GRAP2,
IL21,
ADRA1A,
ADRA2B,
LOC110283621,
BUB1,
HERPUD1,
SART3,
AGRP,
SUPT7L,
MIR150,
RN7SL263P,
BRS3,
KMT2C,
NAMPT,
PDLIM2,
GPHN,
DLEU1,
SUGP1,
PIAS3,
LOC102724334,
JAG1,
AHR,
CFDP1,
MIR155,
MIR146A,
PBK,
GEMIN4,
ASZ1,
RBM45,
ATF3,
SLC12A9,
NLRP3,
ATL1,
POLK,
NCKIPSD,
IL17F,
FOXP2,
PWWP3A,
H2BS1,
ZDHHC16,
ASCC2,
TMED9,
USP44,
PLVAP,
TM9SF3,
AHI1,
ARTN,
FEZF2,
URM1,
THUMPD1,
FASLG,
TDP1,
PAG1,
EPC1,
HDAC8,
NSFL1C,
SPOCK3,
ACKR3,
MIR145,
IL21R,
MIR126,
SACM1L,
TPX2,
TBC1D9,
MIR106A,
DICER1,
TBPL2,
SLC44A1,
BAX,
RNF19A,
TIGAR,
POT1,
APC,
ATL3,
POLDIP2,
IFT172,
PTPN22,
TINF2,
LAT,
PCBP4,
SND1,
ANK1,
AMFR,
NRK,
BAK1,
BAD,
CENPV,
TLX3,
CADM4,
CLDN10,
CCNB1,
BCL10,
LBR,
SMAD3,
LTA,
LMO1,
LIF,
LGALS3,
LGALS1,
LCT,
LCN2,
KIT,
MAS1,
CUX1,
CX3CR1,
CYP1A1,
JAK1,
ITGB7,
DDIT3,
ITGB1,
ITGAX,
SMAD7,
ADAM11,
DNTT,
MTTP,
NRF1,
CISH,
CNOT3,
NFKB2,
NFE2L1,
ATF2,
CRK,
MUC1,
MTHFR,
MDM4,
ABCC1,
MRC1,
MMP7,
MMP2,
KMT2A,
MLH1,
MIP,
MAPK14,
DLG1,
IRF3,
CDK5R1,
FN1,
EPOR,
FCGR3A,
IRF8,
FCGR3B,
FOXN2,
HSF1,
TLX2,
FKBP4,
HAL,
EP300,
MTOR,
GSTM1,
GSN,
GPR42,
GLP1R,
GFI1,
GDNF,
GBP2,
IFNB1,
IGH,
ING1,
EGFR,
IL17A,
IL16,
E2F4,
EDNRA,
EGF,
CXCL8,
IL7,
IL6R,
IL5,
IKBKB,
EGR1,
IL3,
IL2RG,
IL2RB,
EIF4E,
EIF4G2,
ELAVL2,
ENO2,
OAS3,
TNFRSF11B,
PCNA,
TRG,
TNFRSF1A,
GATA4,
TMSB4X,
CCND3,
CD3D,
TFRC,
CD3G,
TERF1,
CD247,
CAV1,
CD5,
CD27,
SSTR4,
SRPK1,
SPTAN1,
SOX4,
CD38,
FSCN1,
TNFRSF1B,
CASP8,
PDE4A,
CA9,
NRP1,
TNFRSF10B,
TNFRSF6B,
ADAM21,
BUB1B,
TP63,
TSPO,
ZNF282,
AIMP2,
TYR,
DEK,
CXCR4,
ZAP70,
WNT5A,
VIM,
VEGFA,
VCP,
CASP2,
SNCA,
SNAP25,
SMARCB1,
MAPK1,
ACTB,
RAB4A,
PTPN13,
PTPN6,
CD68,
CD69,
PSMD2,
MAP2K7,
CD70,
PMEL,
CD151,
PMS1,
PLEK,
PLAU,
PIN1,
CDK9,
PIM1,
CES1,
RAF1,
RBL2,
RBP4,
OPN1LW,
CCL21,
CCL20,
CCL18,
CCL2,
CCL1,
SCT,
CLEC11A,
SATB1,
S100B,
S100A1,
RPL17,
RORC,
RNASE3,
RGS1,
RENBP,
CD44,
REL,
ABL1
Drugs
A lentiviral vector pseudotyped by the Indiana serotype of the vesicular stomatitis virus G protein encoding an antigen derived from the Tax, HBZ, p12I and p30II HTLV-1 proteins,
A lentiviral vector pseudotyped by the New-Jersey serotype of the vesicular stomatitis virus G protein encoding an antigen derived from the Tax, HBZ, p12I and p30II HTLV-1 proteins,
A-dmDT390-bisFv(UCHT1)
A lentiviral vector pseudotyped by the Indiana serotype of the vesicular stomatitis virus G protein encoding an antigen derived from the Tax, HBZ, p12I and p30II HTLV-1 proteins,
A lentiviral vector pseudotyped by the New-Jersey serotype of the vesicular stomatitis virus G protein encoding an antigen derived from the Tax, HBZ, p12I and p30II HTLV-1 proteins,
A-dmDT390-bisFv(UCHT1),
Adenovirus-Interferon gamma - coding DNA sequence,
Alisertib,
Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus,
Belinostat
(
BELEODAQ
),
Brentuximab vedotin
(
ADCETRIS
),
Chlormethine
(
Ledaga
),
Darinaparsin,
Denileukin diftitox,
Fenretinide,
Forodesine hydrochloride,
Human monoclonal antibody against CD4,
Humanised IgG1 monoclonal antibody against human KIR3DL2,
Iodine (131I) tositumomab,
Miltefosine
(
IMPAVIDO
),
Mogamulizumab
(
POTELIGEO
),
N-(2-aminophenyl)-4-(1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin)benzamide,
Naloxone hydrochloride dihydrate,
Panobinostat
(
FARYDAK
),
Pralatrexate
(
FOLOTYN
),
Recombinant anti-CD3-bi-single-chain-Fv-diphtheria toxin fusion protein,
Resiquimod,
Romidepsin
(
ISTODAX
),
Sintilimab,
Siplizumab,
Suberolylanilide hydroxamic acid,
Synthetic hypericin,
Vorinostat
(
ZOLINZA
),
Zanolimumab,
haematopoietic stem cells and blood progenitors umbilical cord-derived expanded with (1R, 4R)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine dihydrobromide dihydrate
Registered!
A rare, virus associated tumor due to human T-cell leukemia virus type 1 or human T-cell lymphotropic virus type 1 (HTLV-1) and is characterized by the presence of anti-HTLV-1 antibodies, and malignant, mature, medium-sized T cells with condensed chromatin and polylobated nuclei. The malignant cells exhibit a mature CD4+ T cells phenotype and express CD2, CD5, CD25, CD45RO, HLA-DR, and T-cell receptor αβ. Presentation is heterogeneous and is typically of aggressive leukemia or lymphoma, variable skin eruptions, and visceral organ involvement.