Granddad Syndrome

Clinical Features

Marion et al. (1989) observed 7 patients who presented a prematurely aged facial appearance and the following features: intrauterine growth retardation with postnatal growth delay, normal mental development, and decreased subcutaneous fat. The facial appearance included triangular facies, prominent forehead, thin or absent scalp hair, deep-set eyes, midfacial hypoplasia, prominent nasal septum with hypoplasia of the alae nasi, prominent ears, and thin lips.

Inheritance

Marion et al. (1989) suggested autosomal dominant inheritance of this disorder because 3 of the patients were from the same family--2 daughters and their father.