Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy
Watchlist
Retrieved
2021-01-23
Source
Trials
—
Genes
CAPN5,
LRP5,
TGFB1,
IL6,
TGFB2,
MDM2,
VEGFA,
TNF,
PIK3CG,
EGF,
CXCL8,
TP53,
PIK3CD,
PIK3CB,
PIK3CA,
HGF,
SMN2,
FN1,
SMN1,
CCL2,
RPE,
LTA,
IL1B,
CXCL1,
GFAP,
MTOR,
TGM2,
FGF2,
PVR,
LGALS1
CAPN5,
LRP5,
TGFB1,
IL6,
TGFB2,
MDM2,
VEGFA,
TNF,
PIK3CG,
EGF,
CXCL8,
TP53,
PIK3CD,
PIK3CB,
PIK3CA,
HGF,
SMN2,
FN1,
SMN1,
CCL2,
RPE,
LTA,
IL1B,
CXCL1,
GFAP,
MTOR,
TGM2,
FGF2,
PVR,
LGALS1,
F2R,
SMAD7,
EDNRB,
EDN1,
MALAT1,
POSTN,
DCN,
CSF2,
TP53BP2,
TCHP,
REN,
RBP4,
SLC12A9,
PTX3,
SLC52A2,
PTN,
PRKCA,
PLG,
PLAT,
DMBX1,
GAL,
TTC36,
PWAR1,
MIR182,
MIR204,
ABCB1,
PGF,
PDGFRB,
ROBO1,
GREM1,
RPS6,
NR1I2,
TNFRSF1B,
TYRP1,
TIMP3,
TIMP1,
SERPINE1,
PLA2G6,
TNFRSF25,
TNFSF10,
LRPPRC,
HPGDS,
TAC1,
STAT3,
YAP1,
CXCL12,
CD226,
CCL19,
CCL27,
TYR,
PCNA,
ABCA4,
OTX2,
OTX1,
F2,
ETS1,
FBL,
EPRS1,
EMP2,
EGFR,
EDA,
HBEGF,
ACE,
CTSS,
CCN2,
CRX,
CDKN1A,
CDK2,
CD44,
CAV1,
CASP3,
BMP7,
BMP4,
BCL2,
CCND1,
BAX,
APOA1,
APC,
ANGPT2,
AMD1P2,
AMD1,
F10,
FGFR1,
FMOD,
ITGA5,
NRAS,
NM,
NFKB1,
MMP2,
MECP2,
MAP1B,
ADM,
LRP1,
LOX,
LGALS3,
KNG1,
KDR,
ILK,
FOS,
IL13,
IL10,
CXCR2,
IL6ST,
IL2,
IGFBP6,
IFNG,
IFNB1,
HSPA4,
HPRT1,
GSK3B,
GP1BA,
MIR21
Drugs
Registered!
A rare, genetic, vitreoretinal degeneration characterized by a slowly progressive vitreoretinopathy with onset during the second or third decade of life. The disease initially presents as autoimmune uveitis with reduction in the b-wave on electroretinography, and progresses with development of photoreceptor degeneration, vitreous hemorrhage, cystoid macular edema, retinal neovascularization, intraocular fibrosis, secondary glaucoma, and retinal detachment leading to phthisis and complete blindness.