Fanconi-Like Syndrome

In 2 brothers, Abels and Reed (1973) described a disorder with both similarities to and differences from the Fanconi syndrome. One brother died in his mid-twenties after a prolonged course characterized by pancytopenia, recurrent infections, low IgA, chronic lung infections complicated by multiple bilateral pneumothoraces, osteomyelitis, and multiple cutaneous malignancies with lymph node metastases. The other brother had severe pancytopenia responsive to methyltestosterone therapy.