Periodic Fever, Aphthous Stomatitis, Pharyngitis And Adenitis

Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) is characterized by short episodes of illness that occur at regular time periods. The syndrome usually occurs in children younger than five years; but it has also been reported in adults. Symptoms of PFAPA include high fevers lasting three to six days occurring every 21 to 28 days, along with body aches, fatigue, mouth sores (aphthous stomatitis), sore throat (pharyngitis), and enlarged lymph nodes (cervical adenitis). In children, the symptoms of PFAPA typically go away after a few years, but in adults the symptoms may continue for years. The cause of PFAPA is unknown, but genetic causes may be involved. PFAPA usually occurs by chance and is not inherited in families. Diagnosis is based on the symptoms and a clinical examination. Treatment is focused on managing the symptoms. Options include tonsillectomy and  medication. Guidelines for the treatment of PFAPA in children have been published.