Ovarian Germ Cell Cancer

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Retrieved

2019-09-22

Source

Omim

Trials

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Genes

CBL, FANCM

Drugs

(5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide, Abagovomab, Adenovirus-associated vector containing human Fas-c gene, Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus, Bevacizumab ( Equidacent, AVASTIN, Aybintio, MVASI ), Defactinib, Doxorubicin hydrochloride (pegylated liposomal) ( CAELYX, DOXORUBICINE TEVA ), Imexon, Maytansinoid-conjugated human monoclonal antibody against mesothelin, Mibefradil, Olaparib ( LYNPARZA ), Patupilone (Epothilone B), Plevitrexed, Pyr-His-Trp-Ser-Tyr-D-Lys(doxorubicinylglutarate)-Leu-Arg-Pro-Gly-NH2, acetate salt, Rucaparib ( RUBRACA ), Treosulfan ( TRECONDI ), Vaccine consisting of 5 survivin peptides with different human leukocyte antigen restrictions, autologous dendritic cells pulsed with killed ovarian cancer cells and matured by TLR3 ligand ex vivo, haematopoietic stem cells and blood progenitors umbilical cord-derived expanded with (1R, 4R)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine dihydrobromide dihydrate, human reovirus type 3 Dearing strain, humanised anti-folate receptor 1 monoclonal antibody conjugated to maytansinoid DM4

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Description

Ovarian germ cell cancers are malignancies that arise from germ cells of the embryonic gonad. Although benign germ cell tumors are relatively common, accounting for approximately 20% of all ovarian neoplasms, malignant ovarian germ cell tumors are rare. Weiss et al. (1977) estimated that less than 5% of ovarian cancers are of germ cell origin.

Inheritance

Jackson (1967) reported a Jamaican family in which grandmother, mother, and daughter developed ovarian cancer (167000); 2 tumors were known to have been dysgerminomas.

Stettner et al. (1999) found previous reports of 6 families in which more than 1 woman had a malignant germ cell tumor, and presented an additional ovarian germ cell cancer family in which a mother, her daughter, and her niece were affected. The affected niece was the offspring of the mother's sister, who had breast cancer. A review of 8 patients with ovarian germ cell malignancies identified 1 who had an uncle with testicular germ cell cancer (see 273300). Stettner et al. (1999) tabulated 6 other instances of familial germ cell malignancies in males and females.