Adenomyosis

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Retrieved

2019-09-22

Source

Omim

Trials

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Genes

MUC16, PGR, ESR1, PIK3CA, BCL2, MTCO2P12, PIK3CB, PTGS2, COX2, MMP9, IL10, CXCL8, IL6, VEGFA, PIK3CG, CYP19A1, PIK3CD, ANXA2, CRH, CCL2, TIMP2, COMT, CXCR4, HOXA10, STAT3, GPER1, MMP2, STIP1, TNF, F3

MUC16, PGR, ESR1, PIK3CA, BCL2, MTCO2P12, PIK3CB, PTGS2, COX2, MMP9, IL10, CXCL8, IL6, VEGFA, PIK3CG, CYP19A1, PIK3CD, ANXA2, CRH, CCL2, TIMP2, COMT, CXCR4, HOXA10, STAT3, GPER1, MMP2, STIP1, TNF, F3, FGF2, CD68, CTNNB1, NOS3, PTEN, AMH, PAK1, CYP2B6, SYT1, TLR4, TGM2, PERCC1, TGFB1, ZEB1, TCF3, TBX1, RELA, MAPK1, ROCK1, MAPK3, PRL, SOD2, MIR21, SELL, MAP3K2-DT, CXCL12, LINC-ROR, SPP1, VWF, MIR17, IL37, CRB3, IL33, MUL1, IL17F, WNK1, IL25, GORASP1, LPAR5, GKN1, TUG1, NDUFA13, PDCD4, FMNL2, SIGLEC7, MIR10B, LPAR3, HECW1, PSIP1, TCFL5, PAK4, CBLL2, ROCK2, LPAR2, EBAG9, BECN1, KHSRP, IL31, TNFRSF1B, MED12, ACTA1, PECAM1, DNMT3A, MSTN, GALT, GABPA, FOXO1, FGF1, EZH2, EPHB4, EPHB2, EGR1, EFNB2, LPAR1, DUSP6, DNMT3B, CYP17A1, GSTM1, CYP1A1, CUX1, CCN2, CNR2, CGA, CEBPB, CDKN2A, CDK2, ENTPD2, CD34, CCK, RHOA, ALOX5, LPAR4, GSTM2, PRKN, LPA, PAPPA, NOTCH1, NINJ1, NHS, AKT1, NGF, NFE2L2, MSH2, MMP7, MMP1, MME, MLH1, MET, LIFR, HCLS1, LIF, LCN2, EIF3E, ILK, IL17A, IL2RB, IL1B, CCN1, IGFBP1, IFNG, HPRT1, HOXA11, HGF, NGFR

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Description

Adenomyosis is characterized by the presence of endometrial glands and stroma within the myometrium. Abnormal uterine bleeding and dysmenorrhea are the most characteristic symptoms, occurring in approximately 65% of cases (Arnold et al., 1995).

Inheritance

Emge (1962) noted a possible hereditary factor in the occurrence of adenomyosis because of his finding of 7 mother-daughter pairs who had undergone surgery for adenomyosis over a 15-year period.

Arnold et al. (1995) reported a family with adenomyosis in 3 successive generations; 2 sisters, their mother, and their maternal grandmother were affected. Either autosomal or X-linked dominant inheritance is possible.