Fixed Drug Reaction
Fixed drug reactions, are common and so named because they recur at the same site with each exposure to a particular medication. Medications inducing fixed drug eruptions are usually those taken intermittently.
Signs and symptoms
A painful and itchy reddish/purple patch of skin that occurs in the same location with repeated exposures to the culprit drug is the classic presentation of a fixed drug reaction. The lips, genitals, and hands are often involved.
Cause
Medications that are commonly implicated as a cause of fixed drug eruptions include the following:
- Cetirizine
- Ciprofloxacin
- Clarithromycin
- Cotrimoxazole
- Doxycycline
- Fluconazole
- NSAIDs (e.g., ibuprofen, Etoricoxib)
- Phenytoin
- Pseudoephedrine
- Trimethoprim
See also
- Drug eruption
- List of cutaneous conditions
- List of human leukocyte antigen alleles associated with cutaneous conditions
- Stevens–Johnson syndrome