Tumor Of The Stomach
Watchlist
Retrieved
2021-01-18
Source
Trials
—
Genes
ERBB2,
APC,
PIK3CA,
FGFR2,
MUTYH,
KLF6,
CDH1,
CASP10,
IRF1,
MET,
CDKN1A,
ATM,
TP53,
KRAS,
CDKN2A,
ERBB3,
AXIN2,
DLC1,
CDK4,
BAP1,
PTGS2,
STAT3,
RUNX3,
IL1B,
MTHFR,
EGFR,
BIRC5,
IL1RN,
TYMS,
TNF
ERBB2,
APC,
PIK3CA,
FGFR2,
MUTYH,
KLF6,
CDH1,
CASP10,
IRF1,
MET,
CDKN1A,
ATM,
TP53,
KRAS,
CDKN2A,
ERBB3,
AXIN2,
DLC1,
CDK4,
BAP1,
PTGS2,
STAT3,
RUNX3,
IL1B,
MTHFR,
EGFR,
BIRC5,
IL1RN,
TYMS,
TNF,
ZNRD1,
GKN1,
CCND1,
GAST,
FHIT,
MUC1,
TYMP,
IL6,
PRNP,
MAPK1,
MMP7,
BRAF,
CD44,
PSCA,
ACE,
DPYD,
XRCC1,
UMPS,
TWIST1,
HMOX1,
IGFBP3,
JUN,
MAPK3,
PPARG,
MYC,
CHFR,
SERPINE1,
HOTAIR,
REG4,
RHOA,
MIA,
MMP10,
PLAU,
SOD2,
CLDN3,
ERCC2,
HRAS,
DCBLD2,
LRRC3B,
PTPRG,
PYCARD,
SMAD4,
CDH2,
CKB,
FAT4,
CDKN1B,
KLK10,
TIMP3,
CAV1,
WWOX,
HBEGF,
KISS1,
PHB,
DNMT3B,
GSTP1,
RPL15,
DNMT1,
BIRC2,
XAF1,
KRT20,
ARL6IP5,
LGALS3,
AHR,
NPM1,
ING1,
SPRR2A,
TNFRSF9,
SNAI1,
ALDH1A3,
SLC1A2,
ALB,
SNRPB,
IL6R,
CXCL8,
ALDOB,
IGFBP7,
HTR1A,
SREBF2,
ALOX5,
TAF15,
APEX1,
FYN,
SPZ1,
ZNF177,
XRCC3,
TUBA1C,
GLI3,
BDNF,
ANXA5,
MIR22HG,
ZNF160,
TPM3,
MBD3L2,
THBD,
HNRNPL,
HOXA2,
TGFA,
TFAP2C,
HSPA8,
HSPB1,
HSPD1,
ITGA5,
ICAM2,
TBX3,
ID4,
IDH3B,
RXRB,
EXOSC5,
RPS26,
PLIN2,
PTPA,
PPP2R1A,
PPIC,
PPIA,
ADRB1,
POLE,
MSX1,
MT2A,
PRR5-ARHGAP8,
PLAGL1,
ZNF667-AS1,
MUC6,
MX1,
RPS21,
CCAT1,
NDUFA2,
NDUFS1,
NDUFV1,
SERPINA1,
PGAM1,
NOS3,
NOTCH2,
PDHA1,
NT5E,
PAX6,
PA2G4,
ADRB2,
PREP,
KMT2A,
MLF1,
RPS19,
RPS15,
RPS6,
RPL18,
AGTR2,
KRT8,
SYMPK,
RORA,
RGS2,
RBP4,
FADS1,
RBP1,
RARRES1,
RARB,
RAD23A,
M6PR,
PTPRF,
ACTC1,
MARK1,
MAPK8,
ATP6V0D2,
AFP,
PRKCB,
PRKAB1,
PRKAA1,
RPL13,
TNFSF9,
ARID1A,
ALDH7A1,
EPHX3,
CDKN2D,
MRPS18B,
CTSC,
PRPF19,
FILIP1,
CLCN3,
CLN3,
SNX5,
ACAD8,
GREM1,
PUS1,
ZBTB20,
SERBP1,
CST1,
PRDX5,
CTNNA2,
CTSL,
BOP1,
APOA1,
FAM168A,
CHEK2,
WIF1,
ULBP2,
DDB1,
GADD45A,
DES,
FSD1,
MRPL13,
DPAGT1,
ABT1,
RANBP10,
BCL2L1,
BID,
BLVRB,
BMP2,
BMP7,
BNIP3,
NAXD,
KMT2C,
RNF43,
CA1,
CA2,
PTOV1,
CASP8,
HRH4,
POLR3K,
MRPS11,
NBAS,
HIKESHI,
UBR5,
GMPR2,
PLCE1,
ZNF593,
UBXN1,
COPS7A,
CPSF1,
ATR,
CCT7,
CYP2A6,
URM1,
SELENBP1,
SCRN1,
MTSS1,
TMEM63A,
ENO1,
WDR46,
IL32,
NOP56,
ERCC1,
AURKB,
RRP9,
SLC16A3,
F2R,
FCGBP,
TRAP1,
SUCLG1,
SERPINB2,
FBP1,
IRS2,
ZNF559,
FGG,
KISS1R,
AKR1C3,
PLPP1,
FKBP2,
CST7,
ITGA8,
AREG,
ARFGAP2,
EEF1A2,
EEF1A1,
EBI3,
CNPY2,
ECM1,
MSLN,
ECHS1,
FST,
TFF1,
REG1A,
IL6ST,
ANXA1,
TXNIP,
MLH1,
CTNNB1,
TERT,
AKT1,
PDGFRA,
MSH2,
FLCN,
KIT,
DCC,
SRC,
VEGFA,
HIF1A,
MSH6,
TERF2IP,
FGFR3,
BUB1B,
ACD,
BUB1,
MC1R,
POT1,
SDHB,
MITF,
MGMT,
CDKN2B,
SDHC,
EP300,
SDHA,
NRAS,
PTEN,
NFKB1,
CDX2,
MMP9,
VEGFC,
GSTM1,
GSTT1,
CASP3,
ABCB1,
PGC,
SPP1,
NOS2,
MMP2,
PTP4A3,
HPSE,
CLDN4,
SOX2,
TGFB1,
SERPINB5,
PLAUR,
POSTN,
WNT2,
TFF2,
MIR21,
PPP1R1B,
CXCR4,
RELA,
AURKA,
SHH,
SSTR3,
H3P10,
IL1A,
CYP2E1,
MUC4,
CCKBR,
FASLG,
FLT1,
MUC5AC,
GLI1,
E2F1,
MUC2,
ANGPT2,
MAD2L1,
ZFHX3,
NR4A1,
OGG1,
CXCL12,
SELE,
CD34,
FOLR1,
ASCL2,
ADAMTS1,
FAS,
CEACAM5,
SEM1,
TIMP2,
TP53INP1,
KRT19,
TNFRSF6B,
LEP,
CFLAR,
LEPR,
IL18,
SP1,
CD9,
TEK,
HGF,
HDAC1,
TGFBR1,
CASP6,
BRCA1,
PDIA3,
GHRL,
CIAPIN1,
HLTF,
WNT5A,
WNT8B,
BCL2,
BAX,
IGF1R,
IL10,
PRDM2,
EZH2,
HLA-DQB1,
SMAD3,
EPHB2,
CYP2C19,
MMP14,
MMP1,
POU5F1,
MIR222,
RASSF1,
MDM2,
MIR196B,
PLA2G2A,
ADIPOQ,
MBL2,
MIR27A,
NGFR,
KLF4,
MAGEA1,
PTCH1,
KLRK1,
IQGAP2,
ARID3B,
UGT1A9,
DACT1,
CCND2,
DACH1,
MZB1,
CLDN18,
TRAK1,
RUNX1,
CCNG2,
DNMT3A,
MPHOSPH8,
ADIPOR1,
HTATIP2,
CA9,
CCNA2,
DEFB4A,
UGT1A10,
CXCR6,
DDR1,
DAPK1,
CASP2,
KIF2C,
MAGED2,
LILRB1,
CBFB,
FXYD5,
DCN,
ZFR,
RAB23,
DDIT3,
CASP7,
IGF2BP3,
CD80,
CD247,
CACYBP,
DAPK2,
NOX1,
TMEFF2,
CCR7,
FOXD3,
CADM1,
COL1A2,
GNL3,
CCN2,
PRKD2,
TINF2,
MAPK14,
CSNK1D,
KLK13,
SETBP1,
SOSTDC1,
CSNK1E,
B3GAT1,
DKK3,
SULF1,
CMA1,
NELFB,
IGK,
KLK12,
RHOBTB2,
CXADR,
CLCF1,
CD40LG,
CD81,
CDC20,
NNT,
CDC25C,
COMMD5,
LPAR3,
TRAC,
CHEK1,
DHDH,
FOXN3,
FOXP1,
CTNNBIP1,
TRPM7,
PGPEP1,
MIR146A,
MIR145,
NCR3LG1,
ANKRD33,
TRIM59,
MRGPRX1,
AGT,
GPRC6A,
AGTR1,
DNAJB1P1,
ABHD11-AS1,
DDX53,
OXER1,
IGSF11,
GATA5,
CLDN23,
GPR151,
ALDH3A1,
ANGPT1,
B4GALNT2,
MRGPRX4,
MRGPRX3,
CAVIN3,
MIR15A,
MIR16-1,
MIR196A2,
PGA3,
PERCC1,
ZFPM2-AS1,
NNT-AS1,
ADAM10,
MIR1226,
ADH7,
ADRA1A,
MIR589,
MIR567,
LGALS7B,
MIR487A,
MIR200B,
ADRA2B,
MIR337,
MIR135B,
GPR166P,
VN1R17P,
MIR301A,
MIR25,
MIR223,
AP2A1,
MIR200C,
PGAP3,
ANXA2,
TSPYL5,
BGN,
LGR6,
HIVEP3,
BDKRB1,
PCDH10,
AICDA,
ACKR3,
ADAMTS9,
BDKRB2,
KCMF1,
RPRM,
CNDP2,
SOX17,
CEACAM1,
LIMS2,
URGCP,
LAPTM4B,
FBXW7,
IMP3,
CDCA8,
PINX1,
IMPAD1,
BRS3,
BACH2,
BAK1,
ANXA4,
ABHD11,
TNS4,
ZNF382,
SPPL2A,
ANXA7,
APAF1,
APOE,
MIEN1,
AR,
RHOC,
DYNLRB1,
RND3,
BAD,
COL18A1,
ARHGDIB,
TET1,
MYCT1,
ASPH,
VASH2,
NEIL1,
ADIPOR2,
ATOH1,
FA2H,
DUSP1,
OPCML,
E2F4,
SAT1,
SDHD,
INPPL1,
INSIG1,
PDX1,
SDC1,
CXCL5,
CCL22,
CCL17,
CCL5,
CCL2,
S100A11,
SFRP1,
S100A8,
S100A6,
IRAK1,
RPS27,
ITGB1,
ITPR3,
KCNA5,
KCNH1,
RPS13,
KCNH2,
SELL,
SIAH1,
TDGF1,
SSAV1,
ID1,
TAZ,
TACC1,
TAC1,
STK11,
ID3,
HSPA13,
CFI,
SSTR4,
IFNGR2,
SRF,
IL12B,
CCN1,
RBPJ,
SPINK1,
IL2,
IL11,
IL12A,
SMO,
SLPI,
SLC5A5,
SLC4A2,
KDR,
KRT18,
RPL6,
PITX1,
MMP11,
MOS,
MPO,
MRE11,
POU2F1,
ABCC1,
PLK1,
PLCG2,
RNR1,
PKD1,
PIK3CG,
RPSA,
CEACAM6,
NEDD4,
NM,
NME1,
NNMT,
PFKFB4,
PFKFB3,
PFKFB2,
PFKFB1,
NPR1,
MKI67,
MIF,
PRKCA,
MGAT5,
RNASE1,
UPF1,
LGALS3BP,
LGALS7,
LOX,
RB1,
LOXL2,
LTA,
EPCAM,
PTPRZ1,
PTPRA,
PTK2,
PTGS1,
MAGEA3,
PSMD10,
MAL,
HTRA1,
KLK6,
MCL1,
MCM7,
PRKDC,
TCF7L2,
TERF1,
PRMT5,
PROM1,
PTTG1,
EREG,
LPAR2,
PDCD5,
ESR1,
MTA1,
SOCS3,
F3,
BTRC,
F8,
FAP,
PIWIL1,
FADD,
ADAM23,
FBLN1,
HRK,
BECN1,
FGF7,
FHL1,
VEGFD,
TNFSF11,
IFITM1,
EPHB6,
RPL23,
TERF2,
PDCD6,
YAP1,
ST3GAL6,
EDNRA,
EFNA1,
EFNB1,
TNK2,
EFNB2,
EGF,
LRPPRC,
ARPC1B,
REC8,
PAGE4,
RBX1,
EPHA2,
ELAVL1,
EIF4A3,
RASSF2,
ENDOG,
AKAP12,
TP53I11,
GDF15,
PCNA,
FLT4,
PPM1D,
RECK,
THY1,
GSK3B,
TUBB2A,
TRPC6,
TPR,
GSPT1,
TP53BP2,
TOP2A,
TLR2,
TIMP1,
TIA1,
THBS1,
NR0B2,
TH,
TGFBR2,
HOXA10,
HPGD,
TFF3,
HSD17B2,
HSPA1B,
HSPA5,
TFAP2A,
ICAM1,
GRIN2B,
UPP1,
VCAM1,
GPR42,
FZD4,
FN1,
FOS,
TKTL1,
MTOR,
FRZB,
NR5A2,
HMGA2,
XRCC6,
FZD5,
GATA3,
GATA4,
ZIC1,
YES1,
XRCC4,
GATA6,
GJB2,
XDH,
WNT2B,
WNT1,
GPI,
NAT2
Drugs
—
Registered!
A gastric tumor is a tumor of the stomach. It can be benign or malignant (gastric cancer). The gastric mucosa is composed of columnar epithelium arranged with pits known as crypts. There are several types of cells that make up gastric mucosa that give rise to gastric tumours: adenocarcinomas comprise 90% of these. Gastric tumours are mostly metastatic and are usually detected at a late stage. They occur more commonly in men than women in the 6th decade of life.
Risk Factors
- Smoking
- Helicobacter pylori infection.
- Diet low in fruits and vegetables.
- Diet high in salt and nitrates.
- Polyps
- Genetic alterations - p53 mutation, microsatellite instability, E-cadherin gene
- Previous radiation
- Pernicious anaemia
Signs and Symptoms
Dysphagia, indigestion, feeling full after eating very little, loss of appetite, nausea, abdominal pain, loss of weight, vomiting blood and passing black stool.
Investigations
Upper Gastointestinal Endoscopy.