Seizures, Benign Familial Neonatal, Autosomal Recessive

For a phenotypic description and a discussion of genetic heterogeneity of benign neonatal seizures, see BFNS1 (121200).

Clinical Features

Schiffmann et al. (1991) described an Iranian Jewish kindred in which 4 children of the same generation in 2 separate sibships with complex parental consanguinity had neonatal seizures. Linkage analysis excluded assignment to the BFNS1 locus on chromosome 20q.

Inheritance

The transmission pattern of benign neonatal seizures in the family reported by Schiffmann et al. (1991) suggested autosomal recessive inheritance.