Vesiculobullous Disease
A vesiculobullous disease is a type of mucocutaneous disease characterized by vesicles and bullae (i.e. blisters). Both vesicles and bullae are fluid-filled lesions, and they are distinguished by size (vesicles being less than 5–10 mm and bulla being larger than 5–10 mm, depending upon which definition is used). In the case of vesiculobullous diseases which are also immune disorders, the term immunobullous is sometimes used. Examples of vesiculobullous diseases include:
- Infectious: (viral)
- Herpes simplex
- Varicella-Zoster infection
- Hand, foot and mouth disease
- Herpangina
- Measles (Rubeola)
- Immunobullous:
- Pemphigus vulgaris
- Pemphigoid
- Dermatitis herpetiformis[1]
- Linear immunoglobulin-A disease (linear IgA disease)
- Genetic:
- Epidermolysis bullosa
Some features are as follows:
| Name | Acantholysis? | Ig |
|---|---|---|
| epidermolysis bullosa | yes | mostly IgG |
| bullous pemphigoid | no | mostly IgG |
| dermatitis herpetiformis | no | IgA |