Restless Legs Syndrome, Susceptibility To, 5

Description

Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation (Bonati et al., 2003).

For additional information and a discussion of genetic heterogeneity of restless legs syndrome (RLS), see RLS1 (102300).

Clinical Features

Levchenko et al. (2006) reported a French Canadian pedigree in which 17 individuals had restless legs syndrome inherited in an autosomal dominant pattern.

Mapping

By genomewide linkage analysis in a French Canadian pedigree segregating restless legs syndrome, Levchenko et al. (2006) identified a 5.2-Mb candidate region, referred to as RLS5, on chromosome 20p13 (maximum multipoint lod score of 3.86 at D20S849).