Polyposis Of Gastric Fundus Without Polyposis Coli

Fundic gland polyposis is marked by the presence of varying numbers of small, sessile polyps restricted to the body and fundus of the stomach. Histologically, it is characterized by proliferation of the fundic glands and cystically dilated glandular ducts. This finding was initially described by Japanese investigators as gastric lesions of familial polyposis coli and Gardner syndrome (Utsunomiya et al., 1974; Watanabe et al., 1978). Fundic gland polyposis was also described in patients with no family history and no polyposis of the colon. Lee and Burt (1986) found no histologic differences between fundic gland polyposis with or without polyposis of the colon. Tsuchikame et al. (1993) described fundic gland polyposis without polyposis coli in a 16-year-old female and subsequently in her 42-year-old mother and 48-year-old father. During a follow-up period of 11 years, no polyps were detected in the antrum, pylorus, duodenum, or colon in the 3 patients, and no extra-alimentary manifestations of Gardner syndrome were found.