Acanthosis Nigricans With Muscle Cramps And Acral Enlargement

Flier et al. (1980) described a brother and sister with insulin resistance, acanthosis nigricans, severe muscle cramps, large puffy hands, and enlarged kidneys. The sister had polycystic ovaries with virilization. Following dilantin treatment, the cramps improved dramatically and in the male insulin resistance decreased. The sibship contained 11 children of whom 1 other may have been affected.