Apnea, Central Sleep

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Retrieved

2019-09-22

Source

Omim

Trials

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Genes

TACR1, TAC1, PHOX2B, VAMP1, INPP5E, PSAP, SLC5A7, CCDC47, PRPS1, TECPR2, FGFR3, DKK1, TBR1, NACC1, QRICH1, MYO9A, H3-3A, RPGRIP1L, AHI1, TMEM216, CEP290, COQ2, AGRN, SLC25A1, SYT2, NADK2, COL13A1, WFS1, CHAT, NALCN, TSEN54, SNAP25, RET, SLC35A2, SLC2A1, ASCL1, SLC18A3, CISD2, CSH2, CSH1, REM1, HSPA9, CENPJ, SLC25A38, ERCC8, ALAS2, ALDH2, EPO, ERCC6, BDNF, ABCB1, GZMB, HMOX1, FOXP3, MIR144, GTF2H5, TGFB1, TPO, ERICD, MIRLET7I, VEGFA, TRPV1, XIST, SLC12A9, DLL1, DLK1, PNO1, PPIF, NES, TBC1D9, SUN1, HSPB7, PHF11, AHR, PSG5, SMN2, CYBB, GTF2H4, GTF2H3, GTF2H2, GTF2H1, MS4A2, ERCC5, ERCC3, ERCC2, CYP3A5, CRP, IL2RB, COMT, CDKN1A, CD38, CAT, MYRF, BMP2, APOE, ANXA5, AKR1B1, IL2RA, IL6, SMN1, PKM, SLC5A3, SFRP1, CCL3, CCL2, AKT1, MAPK3, PPID, PON1, PLCB4, PECAM1, IL7R, PCYT1A, OLR1, NOS3, MET, LEP, ISG20, INSRR, IL18, IL10, CERNA3

Drugs

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Sequeiros and Martins da Silva (1988) studied a large family with 6 cases of sudden infant death syndrome (SIDS; 272120) and at least 4 cases of infantile sleep apnea ('near-miss SIDS') that occurred in 2 successive generations. They postulated that a structural CNS defect or a delay in maturation inherited in an autosomal dominant manner predisposes to SIDS in this family, with peak risk at about age 3 months. Survivors may suffer from recurrent episodes of infantile apnea or be completely asymptomatic. Somnograms remained abnormal as late as age 5 years.