Interdigitating Dendritic Cell Sarcoma
Watchlist
Retrieved
2021-01-23
Source
Trials
—
Genes
BCL2,
BCL6,
HLA-DRB1,
CHEK2,
RAD54B,
BCL10,
FPGS,
RAD54L,
EPHX1,
MTHFR,
CYP2E1,
CSF3,
CSF2,
IFNA2,
TYMS,
PRF1,
CBS,
CASP10,
TFRC,
SHMT1,
BHMT,
TNFRSF8,
ALK,
PDLIM7,
PTPRC,
NCAM1,
ADA,
BRAF,
CHP1,
NDRG2
BCL2,
BCL6,
HLA-DRB1,
CHEK2,
RAD54B,
BCL10,
FPGS,
RAD54L,
EPHX1,
MTHFR,
CYP2E1,
CSF3,
CSF2,
IFNA2,
TYMS,
PRF1,
CBS,
CASP10,
TFRC,
SHMT1,
BHMT,
TNFRSF8,
ALK,
PDLIM7,
PTPRC,
NCAM1,
ADA,
BRAF,
CHP1,
NDRG2,
H3P19,
TNF,
LOC102724971,
LOC102723407,
TP53,
SLC35B2,
NRSN1,
ATAD1,
VIM,
TPPP,
RTEL1,
RFXANK,
SCAPER,
IGHV3-52,
HDAC9,
SIRPB1,
CCT4,
TMED2,
SOX10,
STAT3,
MYC,
SOD2,
HSPA4,
BTK,
CASP3,
CD9,
CDKN2A,
CLTA,
ADAM3A,
DCK,
EZH2,
NR3C1,
GUCA1B,
GUCY2D,
HNMT,
HSPA8,
RNASEL,
IFNB1,
IGH,
IL1B,
IL4,
CXCL8,
IL10,
IRF4,
LIF,
LMNB1,
SERPINB2,
PLG,
RARA,
H3P10
Drugs
Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus,
Anti-CD123 IgG1 humanised monoclonal antibody conjugated to N1-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)-N6-((S)-1-(((S)-1-((3-((((S)-8-methoxy-6-oxo-11,12,12a,13-tetrahydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-9-yl)oxy)methyl)-5-((((S)-8-methoxy-6-oxo-12a,13-dihydro-6Hbenzo[5,6][1,4]diazepino[1,2-a]indol-9-yl)oxy)methyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)adipamide,
haematopoietic stem cells and blood progenitors umbilical cord-derived expanded with (1R, 4R)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine dihydrobromide dihydrate
Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus,
Anti-CD123 IgG1 humanised monoclonal antibody conjugated to N1-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)-N6-((S)-1-(((S)-1-((3-((((S)-8-methoxy-6-oxo-11,12,12a,13-tetrahydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-9-yl)oxy)methyl)-5-((((S)-8-methoxy-6-oxo-12a,13-dihydro-6Hbenzo[5,6][1,4]diazepino[1,2-a]indol-9-yl)oxy)methyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)adipamide,
haematopoietic stem cells and blood progenitors umbilical cord-derived expanded with (1R, 4R)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine dihydrobromide dihydrate
Registered!
A rare dendritic cell tumor characterized by a neoplasm composed of spindle to ovoid cells with phenotypic features similar to those of interdigitating dendritic cells. Solitary lymph node involvement is common, although extranodal localization (in particular skin and soft tissue) has also been reported. Patients usually present with an asymptomatic mass, sometimes with systemic symptoms such as fatigue, fever, and night sweats. Generalized lymphadenopathy, splenomegaly, or hepatomegaly may be seen in rare cases. The clinical course is generally aggressive.