Tuberous Sclerosis Complex
Watchlist
Retrieved
2022-04-26
Source
Trials
—
Genes
TSC2,
TSC1,
IFNG,
EIF4EBP1,
PKD1,
PIK3CB,
TESC,
SLC12A3,
PIK3CD,
PIK3CG,
MTOR,
PIK3CA,
PTEN,
AKT1,
TP53,
STK11,
IGF1,
RPS6KB1,
DDIT4,
TYMS,
RASA1,
OGG1,
BRAF,
IL1B,
CCL26,
VDR,
IL6,
PRKAA1,
PRKAA2,
PRKAB1
TSC2,
TSC1,
IFNG,
EIF4EBP1,
PKD1,
PIK3CB,
TESC,
SLC12A3,
PIK3CD,
PIK3CG,
MTOR,
PIK3CA,
PTEN,
AKT1,
TP53,
STK11,
IGF1,
RPS6KB1,
DDIT4,
TYMS,
RASA1,
OGG1,
BRAF,
IL1B,
CCL26,
VDR,
IL6,
PRKAA1,
PRKAA2,
PRKAB1,
RHEB,
MAPK1,
GH1,
PRKD1,
MIR21,
ABCB1,
TBC1D7,
PTGS2,
BCL2L11,
GRM5,
COX2,
MFAP1,
MEN1,
RGS6,
NF1,
FMR1,
VIM,
TERF2IP,
PCNA,
RABGEF1,
CRTC1,
VEGFA,
VEGFC,
PTPN4,
MIR147B,
MIR146A,
MIR132,
RPS6,
C20orf181,
TNF,
RAP1A,
FLCN,
MTCO2P12,
EGF,
ABO,
EPHB2,
MAPK3,
EGFR,
APRT,
DCX,
LRPPRC,
ST14,
SPP1,
AKT3,
DEPDC5,
STIM1,
SPINT1,
GRAP2,
ADIPOQ,
LILRB2,
KLF4,
STAT3,
IRS2,
CDK5R1,
RIPK2,
ELOC,
TCOF1,
GLRX3,
CASK,
IKBKG,
SLC7A5,
HMGA2,
AIMP2,
YWHAZ,
YWHAB,
TFRC,
TRPC4,
TYR,
ZNRD2,
ABCA4,
AHSA1,
WNT3A,
ARID1B,
RPTOR,
CIP2A,
GRHL3,
IL21,
NEUROG2,
DHDDS,
FUZ,
COL18A1,
CCDC8,
BEX2,
ORAI1,
LINGO1,
UBASH3B,
CDCA5,
DCTN6,
PLB1,
RMDN2,
MARCHF10,
HEXD,
TICAM2,
MIR142,
MIR223,
PIM3,
OPN1MW2,
IH,
TMED7-TICAM2,
FECD3,
OPN1MW3,
UPK3B,
SLC12A5,
RALGAPB,
CHPT1,
WDR45B,
TNFSF13B,
OGA,
NES,
UTS2,
TRIM31,
WDR45,
PARK7,
DKK1,
TBC1D9,
PHLPP1,
RPGRIP1L,
MLYCD,
AMACR,
PPP1R15A,
RNF19A,
POLDIP2,
BEX3,
LAT,
SGSM3,
NOX4,
IL21R,
IL22,
TMED7,
RMDN1,
TLR7,
TNFRSF12A,
IL23A,
RMDN3,
SYBU,
SOX9,
PSMD9,
SLC12A2,
CTLA4,
DBH,
DECR1,
NQO1,
EIF4G1,
EREG,
PTK2B,
FCN2,
FLNA,
FLT1,
FLT4,
GABPA,
GC,
GCHFR,
OPN1MW,
GFAP,
GJA1,
GCLC,
GNA11,
GNA12,
GPT,
GRN,
GRIN2C,
GSK3B,
HCRT,
HGF,
HMBS,
HRAS,
CTNNB1,
CCN2,
SLC2A1,
CSF2,
ACTB,
AGER,
AKT2,
AMELX,
AMH,
ANXA1,
ANXA6,
AQP4,
ARNTL,
ATM,
KIF1A,
CCND1,
BCL2,
OPN1SW,
BDNF,
BMP4,
C1QBP,
CANX,
CBR1,
CD8A,
CDK7,
CDKN2A,
CDX2,
CLN3,
CMM,
CRK,
MAPK14,
HTR2C,
ICAM1,
IFI27,
IKBKB,
TNFRSF11B,
PRDX1,
PAH,
PAK2,
PAM,
PDCD1,
PDGFRB,
PEX13,
PIK3C3,
PITX1,
PLA2G1B,
PLCD1,
PLG,
PRRX1,
POMC,
ABL1,
PTGS1,
PVALB,
RAP1GAP,
RBBP4,
S100A1,
S100B,
CCL2,
CCL24,
SDC2,
SDHB,
SHOX,
NTF4,
NTF3,
NPC1,
MME,
IL4,
IL6ST,
CXCL8,
IL12A,
IL17A,
ING2,
INHA,
IRF7,
IRS1,
KRAS,
LAMC2,
LIG4,
MMP2,
NOTCH1,
MNAT1,
MPP2,
ABCC1,
MYO1B,
COX1,
MTTP,
MUC1,
MYC,
NFE2L2,
NFKB1,
NGF,
NM,
H3P23
Drugs
Registered!
Tuberous sclerosis complex (TSC) is characterized by the growth of benign tumors throughout the body, including in the heart, brain, and kidneys. Certain symptoms develop before to birth, such as heart tumors (rhabdomyoma). Other symptoms become more obvious in childhood, such as developmental delay and skin changes. Lung and kidney tumors are more likely to develop in adulthood. TSC is caused by the TSC1 or TSC2 gene not working correctly. It is inherited in an autosomal dominant pattern. This condition is diagnosed based on a clinical exam, medical tests such as imaging studies, and genetic testing. Treatment is based on managing the symptoms, and includes medications and surgery.