Monocyte Chemotactic Disorder

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Retrieved

2019-09-22

Source

Omim

Trials

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Genes

IL17RC, STAT1, IL17F, IL17RA, TRAF3IP2, CLEC7A, AIRE, STAT3, RFXAP, ZNF341, EPG5, RFXANK, RFX5, CIITA, SP110, IL17A, CARMIL2, CARD9, NUDT11, IL22, STAT2, IL12RB1, IL10, IFNG, IL23A, HDAC9, CSF2, PTPN22, DOCK8, MAPK8

Drugs

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In a 9-year-old girl with chronic mucocutaneous candidiasis and cutaneous anergy, Snyderman et al. (1973) found that mononuclear leukocytes failed to migrate in vitro toward two chemotactic stimuli, leukocyte-derived chemotactic factor and C5A. After treatment with transfer factor, the patient's monocytes responded to both chemotactic factors. There is no information on the genetics of this presumably genetic disorder, but autosomal recessive inheritance is a reasonable presumption. Deficiency of leukocyte myeloperoxidase has been found with disseminated candidiasis (254600). In other cases chronic mucocutaneous candidiasis has been related to a deficiency of lymphokine (247650) or a defect in lymphocyte transformation that either is intrinsic (247450) or results from inhibition by a serum factor (247430).