Nail-Patella-Like Renal Disease

Salcedo (1984) described a family in which 3 children of first-cousin parents of Palestinian Arabic ancestry had proteinuria and renal impairment from an early age. Two of the sibs died at ages 6 and 7 years of end-stage renal disease. Renal biopsy in the proband showed the histopathologic electron microscopic changes of the nail-patella syndrome (161200); however, none of the family had bone or nail changes of this disorder. An autosomal recessive nephropathy or glomerulodysplasia was suggested.