Growth Retardation, Small And Puffy Hands And Feet, And Eczema

In 2 sisters and a boy born of consanguineous parents, Grubben et al. (1992) demonstrated an apparently new syndrome of pre- and postnatal growth deficiency, hypotonia, psychomotor retardation with notably impaired speech development, small and puffy hands and feet, small and widely spaced teeth, eczematous skin, and, in one of the sisters and the boy, partial agenesis of the corpus callosum.