Trigeminal Neuralgia

Watchlist

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Retrieved

2019-09-22

Source

Omim

Trials

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Genes

MAPK3, MAPK1, CALCA, FOS, GFAP, GRIN1, IL1B, TNF, PRKCG, MAPK8, MAPK9, AIF1, CDK5R1, CDK5, SUFU, NF2, PRNP, SMARCB1, ERBB2, PDGFB, BRCA1, EGFR, ESR1, MS, CRLF1, GADL1, MVD, AZIN2, BMP2, MIR148A

MAPK3, MAPK1, CALCA, FOS, GFAP, GRIN1, IL1B, TNF, PRKCG, MAPK8, MAPK9, AIF1, CDK5R1, CDK5, SUFU, NF2, PRNP, SMARCB1, ERBB2, PDGFB, BRCA1, EGFR, ESR1, MS, CRLF1, GADL1, MVD, AZIN2, BMP2, MIR148A, MIR195, MIR324, MIR375, MALAT1, TP53, TP53BP1, TYR, AIMP2, TNFSF10, TIMP3, SNORD116@, CTAG1A, GRAP2, TRPM3, CASP8AP2, CAMKMT, FRTS1, TRPV4, TENM3, FEV, PPP1R2C, VGLL1, GPN3, TAZ, ANTXR2, RSS, CD274, PRIMA1, POLDIP2, RNF19A, PANX1, PPARGC1A, AHSA1, TG, ACLY, STAT3, CALM3, CTNNB1, CTAG1B, MAPK14, CRK, CPE, CHRM3, KRIT1, CALR, CALM2, SMS, CALM1, CAD, TSPO, BDNF, AR, ALB, JAG1, AFP, CYP3A4, DDX3X, DHCR24, FGF2, SLC6A4, PIM1, PARP1, SERPINE1, P2RX7, P2RX3, ORM2, NME1, NGFR, MYC, MUC1, MMP9, LBP, KRT14, JAK2, IL6, HLA-B, CD24

Drugs

(5R)-5-(4-{[2-fluorophenyl)methyl]oxy}phenyl)-L-prolinamide, hydrochloride

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Harris (1936) observed 9 cases in 3 generations. Allan (1938) described the condition in a 32-year-old man, his maternal uncle and his maternal grandmother. Argenta (1959) noted the disorder in 3 sibs, 2 of whom were twins. Auld and Buermann (1965) observed a family with 6 out of 7 sibs affected; no comment on parental consanguinity was made. I studied a family (K.L., 945011) in which 5 persons in 4 sibships and 3 generations were affected. There were 2 instances of apparent lack of penetrance ('skipped generations'). Herzberg (1980) reported 4 cases in 3 generations. Kirkpatrick (1989) described classic trigeminal neuralgia in 3 sisters who had a paternal aunt who may have also been affected.