Kienbock Disease Watchlist (log in to enable) Retrieved 2021-01-23 Source Orphanet Trials — Genes MMP2, SERPINE1 Drugs — Interested in hearing about new therapies? Registered! Kienbock disease is a rare bone disorder of unknown etiology characterized clinically by osteonecrosis of the carpal lunate, eventually leading to collapse of the lunate bone impacting wrist function.