Gastrocutaneous Syndrome

Clinical Features

Halal et al. (1982) described a French Canadian kindred with these features in multiple persons in an autosomal dominant pedigree pattern. The proband, a 14-year-old girl, presented with bleeding antral ulcer; she had had pigmented spots over the back since age 2 years and wore spectacles for myopia from an early age. Male-to-male transmission was noted. Other syndromes with peptic ulcer are multiple endocrine neoplasia (131100) and the tremor-nystagmus-ulcer syndrome (190310).