Osteoma Of Cranial Vault, Familial

Ruggieri et al. (1998) described solitary osteoma of the parietal skull in a mother and her 12-year-old son. There were no other craniofacial or dysmorphic features. There was no history of previous cranial trauma or inflammatory process and no radiographic evidence of other skeletal lesions. The family history was otherwise unremarkable. Gardner syndrome (175100), which is characterized by cranial osteomas at other sites as well as soft tissue tumors in association with colonic polyposis was ruled out by excluding other associated clinical abnormalities and by the lack of family history of colonic disease.