Cranioacrofacial Syndrome

Grosse (1974) described associated cardiac, craniofacial and hand anomalies in a father and daughter. The cardiac defect was combined ventricular septal defect and pulmonic stenosis. The craniofacial 'defect' consisted mainly of narrow head and face. Very minor abnormalities were present in the hands, e.g., Dupuytren contractures in the father.