Acth-Dependent Cushing Syndrome

Watchlist

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Retrieved

2021-01-23

Source

Orphanet

Trials

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Genes

POMC, GHSR, PRL

Drugs

2S,4R ketoconazole, Ketoconazole ( KETOCONAZOLE HRA, NIZORAL ), Mifepristone ( KORLYM )

2S,4R ketoconazole, Ketoconazole ( KETOCONAZOLE HRA, NIZORAL ), Mifepristone ( KORLYM ), Osilodrostat ( ISTURISA ), Pasireotide ( SIGNIFOR, SIGNIFOR LAR ), Relacorilant, Synthetic double-stranded short interfering RNA oligonucleotide directed against proopiomelanocortin

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A form of endogenous Cushing syndrome (CS) caused by abnormal production of ACTH due, in 80% of cases, to adrenocorticotropic hormone (ACTH) oversecretion by a pituitary adenoma (Cushing disease, CD) and in 20% of cases to ectopic ACTH secretion (CS due to EAS) by an extrapituitary tumor (in 50% of cases originating in the lungs or less commonly in the thymus, pancreas, adrenal gland or thyroid) or very rarely due to a tumor secreting both ACTH and corticotrophin-releasing hormone (CRH).