Fg Syndrome 3

For a general phenotypic description and a discussion of genetic heterogeneity of FG syndrome, see FGS1 (305450).

Mapping

Dessay et al. (2002) studied 2 families with FGS, 1 American and 1 English, in which linkage to the FGS1 and FGS2 (300321) loci on the long arm of the X chromosome was excluded. Linkage was found, however, with locus DXS1060, suggesting that a third FG locus may be located at Xp22.3.

Molecular Genetics

Exclusion Studies

By sequence analysis in affected members of 2 families with FGS3, Dessay et al. (2002) excluded involvement of 2 candidate genes, VCXA (300229) and PRKX (300083).