Multiple Endocrine Neoplasia Type 2a

Watchlist

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Retrieved

2022-04-26

Source

Gard

Trials

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Genes

RET, CALCA, MEN1, RBP3, SDHD, NTRK1, MT1A, GDNF, ITGB1, VHL, HNRNPA3P1, HNRNPA3, PNMT, SLC16A1, SDHB, MCAT, MCPH1, AR, TGM2, S100A12, RYK, SDHC, SLC6A2, ABO, SLC18A1, SLC18A2, PTEN, TP53, VEGFA, VGF

RET, CALCA, MEN1, RBP3, SDHD, NTRK1, MT1A, GDNF, ITGB1, VHL, HNRNPA3P1, HNRNPA3, PNMT, SLC16A1, SDHB, MCAT, MCPH1, AR, TGM2, S100A12, RYK, SDHC, SLC6A2, ABO, SLC18A1, SLC18A2, PTEN, TP53, VEGFA, VGF, ZNF22, NCOA4, OSMR, SIN3A, SESN2, IL31RA, MIR885, TH, NPY, PRL, POMC, BRCA1, BRCA2, CEACAM5, CFTR, CGA, CHGA, DBH, ACE, EGR1, EIF4G1, EPAS1, EPO, ESR1, FH, GC, GCG, GPT, NR3C1, HLA-H, HNRNPF, HP, MAZ, MBL2, MT2A, MT2P1, NF1, AKT1, MIR1225

Drugs

Thyrotropin alpha ( THYROGEN )

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Multiple endocrine neoplasia type 2A (MEN 2A) is is an inherited disorder caused by mutations in the RET gene. Individuals with MEN 2A are at high risk of developing medullary carcinoma of the thyroid. About 50% will develop pheochromocytoma, a tumor of the adrenal glands which may increase blood pressure. Individuals with MEN 2A are also at increased risk for parathyroid adenoma or hyperplasia (overgrowth of the parathyroid gland). Occasionally an itchy skin condition called cutaneous lichen amyloidosis also occurs in people with type 2A disease. The condition is inherited in an autosomal dominant manner.