Acanthosis Nigricans-Insulin Resistance-Muscle Cramps-Acral Enlargement Syndrome

This syndrome is characterised by the association of acanthosis nigricans, insulin resistance, severe muscle cramps and acral hypertrophy.

Epidemiology

At least five cases have been described in the literature so far.

Clinical description

Enlargement of the kidneys was also reported in some cases.

Genetic counseling

Transmission is autosomal recessive.