Susceptibility To Viral And Mycobacterial Infections Due To Stat1 Deficiency

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Retrieved

2021-01-23

Source

Orphanet

Trials

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Genes

STAT1, CYP7B1, FRMPD1, BICRA, IKBKG

Drugs

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Susceptibility to viral and mycobacterial infections is a rare, genetic, primary immunodeficiency due to a defect in innate immunity disorder characterized by impaired intracellular signaling from both type I and type II interferons, leading to early-onset, severe, life-threatening intracellular bacterial (typically mycobacteria) and viral (mainly herpes viruses) infections.