Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation
Watchlist
Retrieved
2021-01-23
Source
Trials
—
Genes
LMNA,
TMPO,
SLC22A5,
DMD,
ADRB1,
TNNT2,
TTN,
MYH7,
ACTC1,
TNNI3,
CTNNB1,
NPPB,
EGFR,
CD36,
MYH6,
NKX2-5,
NPPA,
RENBP,
PSEN1,
CPT2,
HFE,
PCCB,
SDHA,
PSEN2,
FAS,
SOD2,
ITGB1,
RAF1,
CSRNP1,
RAC1
LMNA,
TMPO,
SLC22A5,
DMD,
ADRB1,
TNNT2,
TTN,
MYH7,
ACTC1,
TNNI3,
CTNNB1,
NPPB,
EGFR,
CD36,
MYH6,
NKX2-5,
NPPA,
RENBP,
PSEN1,
CPT2,
HFE,
PCCB,
SDHA,
PSEN2,
FAS,
SOD2,
ITGB1,
RAF1,
CSRNP1,
RAC1,
PCCA,
ADRB2,
ALMS1,
FASN,
AXIN2,
TCF7L2,
NR3C2,
PNPLA2,
SIK1,
ABRA,
UCP1,
SHBG,
ATM,
CSF3,
WDR12,
GPX1,
MMUT,
FASLG,
MMACHC,
GBE1,
DOT1L,
MYBPC3,
TUBB,
HAND2,
PLN,
BAG3,
ESR1,
TGFB1,
RBM20,
HAND2-AS1,
ERBB2,
CACNB4,
SCN5A,
TP53,
MGAM,
GATA4,
ACE,
ACTB,
DES,
TPM1,
CSRP3,
TNF,
VEGFA,
NFE2L2,
TNNC1,
NLRP3,
PGR,
PIK3CA,
GABPA,
HLA-DRB1,
SGCD,
TBX20,
SMUG1,
TIMP1,
HLA-DQB1,
RBM45,
GSK3B,
HLA-DQA1,
MUC2,
MARCKSL1,
AR,
IL1B,
MMP9,
IL6,
TAZ,
SRF,
MST1,
BCL2,
REN,
MIR21,
CASP3,
PIK3CB,
PIK3CD,
PIK3CG,
FLNC,
ACE2,
PTEN,
MYPN,
GJA1,
EDN1,
FOXO1,
HIF1A,
CASR,
AKT1,
VCL,
HSPB7,
SIRT3,
LGALS3,
MMP1,
MYC,
CCND1,
AGT,
STAT3,
CCN2,
TLR4,
IL2RA,
MIR499A,
IGF1,
PECAM1,
ADIPOQ,
MIAT,
EPHB2,
FN1,
KIT,
VIM,
GAPDH,
POSTN,
ANKRD1,
CDH1,
ROS1,
SIRT1,
OBSCN,
FSD1,
FGF21,
FSD1L,
ZBTB17,
NOS3,
NOTCH1,
CD59,
PRKAA1,
FOXP3,
SULT1E1,
MAPK1,
IL10,
CASZ1,
MAPK3,
DSP,
ISG20,
PRKAA2,
SLC2A4,
SLC2A1,
PRKAB1,
SPP1,
EDNRA,
HAND1,
TNNI3K,
PKP2,
IL17A,
CXADR,
ISL1,
PRKG1,
SERPINE1,
CHPT1,
HLA-C,
PPP2CA,
LY75,
PPARA,
MYOZ2,
COX2,
MYL3,
PRKD1,
HRC,
FOXP1,
PON1,
LDB3,
KDR,
MAOA,
IL1RN,
CXCL8,
IL1A,
SMAD4,
MMP2,
PDLIM3,
MMP14,
DNAJB1,
PDE3A,
PTGS2,
NUS1P3,
PTPRC,
MAPK8,
SYNE1,
CTNNA3,
NUS1,
SOD1,
CTH,
DNAJA3,
LRRC10,
CPT1A,
SYK,
CRYAB,
MAPK14,
CTLA4,
MIRLET7B,
CTRL,
APLN,
MIR671,
DNAJB1P1,
DBT,
MIR675,
TBX5,
BGLAP,
HDAC3,
TIMP2,
MIR214,
KL,
RUNX3,
TM7SF2,
CD68,
TIMP3,
CDKN2A,
LMOD2,
THBS1,
CALR,
CHI3L1,
GDF15,
VPS51,
MIRLET7I,
DNAH8,
CAT,
NR1H3,
CAP2,
ACTA2,
NRG1,
ADM,
RRM2,
PDPN,
GRK2,
MTOR,
MYOCD,
TXNRD2,
MIR208B,
FBXO32,
JAG1,
CCL2,
NEBL,
ANGPT2,
EYA4,
ENO1,
ANGPT1,
ST3GAL4,
EDNRB,
TNFRSF6B,
TCAP,
PROM1,
LTBP4,
DDAH2,
PRSS12,
SETD1B,
PLEKHM2,
SRRM2,
ELP1,
NPTXR,
KLF4,
SOCS3,
PIWIL1,
IL1RL1,
ESYT1,
SQSTM1,
IL18R1,
TIMELESS,
CCNB2,
DLK1,
MKNK1,
LILRB1,
NLRP1,
NCOA6,
KCNQ1OT1,
ATP6AP2,
TSHZ1,
SPRY1,
YAP1,
ADAMTS8,
DDAH1,
SMC2,
PDLIM5,
NAMPT,
MYL12A,
KHDRBS1,
CELF1,
CORIN,
MORF4,
NES,
PPARGC1A,
EBI3,
ABCC9,
KDM2A,
VASH1,
AIM2,
ATF6,
RBM39,
KMT2B,
MMRN1,
HDAC4,
PPP1R13L,
BMS1,
HDAC6,
DOLK,
DUSP12,
RASSF1,
WDHD1,
RB1CC1,
MFN2,
NR1H4,
ABO,
ACKR3,
DAPK2,
MIR126,
MALAT1,
IL31,
C4orf3,
MIRLET7C,
MIR106A,
MIR106B,
MIR10B,
MIR132,
SLC35B2,
MIR139,
MIR144,
MIR146A,
MIR155,
MIR15B,
MIR17,
MIR185,
GSTK1,
NEAT1,
MIR200B,
PPM1K,
SLCO6A1,
PPARGC1B,
GATA5,
SERPINA12,
ZNF418,
IL23R,
PLB1,
BTNL9,
IL27,
AGR3,
XIRP1,
DDX53,
ADAMTS18,
MLKL,
PRSS55,
RBM24,
MIR186,
MIR200C,
NUP62,
LINC01672,
MIR639,
MIR646,
MIR92B,
MIR454,
MIR216B,
TIMM23,
MIR3908,
LUCAT1,
MIR636,
ADAMTS9-AS2,
LY75-CD302,
MIR5571,
SCHLAP1,
ZASP,
MTCO2P12,
ORI6,
MIR638,
MIR551B,
MIR203A,
MIR30C2,
MIR208A,
MIR22,
MIR223,
MIR23A,
MIR25,
MIR27A,
MIR30C1,
MIR320A,
POU5F1P4,
EIF2AK4,
MIR133B,
MIR424,
MIR451A,
MIR497,
POU5F1P3,
CRNDE,
DNAJC19,
ACVR1C,
XIRP2,
TRPM7,
CHCHD2,
DCTN4,
PIPOX,
SCARA3,
IL17D,
SOX18,
DGCR8,
PIWIL2,
IL22,
PNPO,
ASXL2,
STAP2,
ERBIN,
SULF2,
MYDGF,
BTNL2,
INSIG2,
NOX4,
TMEM150A,
PDCD4,
IL17RA,
PRPF6,
TNFAIP8,
TXN2,
ITGB1BP2,
HAVCR1,
CACYBP,
PCDH17,
DUOX2,
RBMS3,
TOR2A,
DLL1,
RGCC,
DROSHA,
NOP53,
EFEMP2,
PNO1,
JPH2,
RHOJ,
MYLK3,
TMPRSS13,
HOPX,
MAK16,
SPZ1,
KDM2B,
COX4I2,
LMLN,
MTDH,
TRIB3,
SFXN1,
MYL12B,
IL17F,
RLN3,
TPH2,
HSPB6,
MYOM3,
SOX7,
ADAM33,
FHOD3,
ADAMTS20,
SUGP1,
GATAD1,
RHOU,
KMT2C,
MYOZ1,
TRPV4,
NIF3L1,
PRDM16,
NOD2,
IFIH1,
FKRP,
VTCN1,
LIN28A,
HDAC11,
MINDY3,
EOMES,
RNASE3,
FXR1,
IL2,
ECE1,
ELANE,
ELK3,
ELN,
EMD,
EPHB1,
EPO,
ESRRB,
F3,
FABP4,
FABP3,
FANCC,
FAT1,
FKTN,
FGFR1,
E2F6,
DUSP5,
DUSP1,
DAG1,
CTSL,
CYBB,
CYP1A2,
CYP2E1,
CYP11B2,
CYP19A1,
ECI1,
DSG2,
DECR1,
DLG1,
DNMT1,
DNMT3B,
DNTT,
ATN1,
FHL2,
FOXG1,
FOS,
HPRT1,
HLA-DPA1,
HLA-DPB1,
HLA-DQB2,
HLA-G,
HMOX1,
HOXA10,
HSD17B2,
HHEX,
HSF1,
HSPA4,
HSPA9,
HSP90AA1,
IDH1,
IFNB1,
HIVEP1,
HGF,
FRZB,
GHSR,
FUT3,
FYB1,
GAB1,
LRRC32,
GATA6,
GCH1,
CBLIF,
HDAC1,
GCLM,
GNAO1,
GOT2,
GPX3,
GSTP1,
GTF2H1,
CTSB,
CST6,
CSH2,
ATP2A2,
APOA1,
APOE,
KLK3,
ARG1,
ATF1,
ATP2A1,
ALDH7A1,
NUDT2,
AXL,
BCL6,
BCL9,
BDH1,
CEACAM1,
BMI1,
APC,
ANXA2,
BRCA1,
APLNR,
ACTN2,
ADAM10,
PLIN2,
ADORA2A,
ADRB3,
AGTR1,
AHR,
SLC25A6,
AHSG,
AKT2,
AMPD1,
ANPEP,
SLC25A4,
SLC25A5,
BMP2,
BRCA2,
CSH1,
CNR1,
CHRM3,
ERCC8,
CLU,
CLIC2,
CMD1B,
CNN1,
COL5A1,
CTSC,
COL5A2,
COL11A1,
COMP,
COX4I1,
COX8A,
CRP,
CHRM2,
CFL2,
TSPO,
CASP1,
CA8,
CA9,
CACNA1C,
CACNB2,
CALM3,
CAPN2,
CAV3,
CDKN1B,
CCND2,
CD34,
CD40,
CD69,
CDH5,
CDK4,
IGF1R,
IL4,
NCOA4,
IL4R,
RYR2,
S100A1,
S100A2,
S100A4,
S100A6,
S100B,
SCD,
SCN2B,
SDC1,
SDC4,
CXCL12,
SDHB,
SFRP1,
SLC5A1,
SLC5A2,
ACACA,
TRIM27,
RET,
PRKCE,
POU5F1,
PPARG,
PPP1R1A,
SRGN,
PRG2,
PRKCD,
MAPK7,
RBP4,
PTBP1,
PTPN11,
PXN,
RASA1,
RASGRF1,
RB1,
SLC6A2,
SLC22A3,
SNAI2,
XIST,
UCP2,
UGT8,
VASP,
VDAC1,
VDR,
WNT5A,
XK,
CRISP2,
YY1,
ZYX,
CXCR4,
PLA2G7,
TFEB,
ARHGEF5,
TWIST1,
TNFRSF1B,
SMARCA4,
TEK,
SOX2,
TRIM21,
ADAM17,
TCF4,
TRBV20OR9-2,
TEAD1,
TFAP2A,
TNFRSF1A,
TGFB2,
TGM2,
TIE1,
TK2,
TMOD1,
CLDN5,
PLIN1,
PIK3R1,
PHB,
TACSTD2,
LMNB1,
LMO7,
LOX,
LRP6,
LTBP2,
LUM,
SMAD2,
LHCGR,
SMAD3,
MAS1,
MBL2,
MDH1,
MDM2,
MECP2,
LIPE,
LEP,
MEF2C,
JARID2,
IL7R,
CXCR2,
IL13,
IDO1,
IRF1,
IRF5,
KCNJ5,
LCN2,
KCNJ8,
KCNJ12,
KNG1,
KRT14,
LAG3,
LAMP2,
MEF2A,
MAP3K5,
PGM1,
OSM,
NEK2,
NFKB1,
NODAL,
NOTCH4,
NPR2,
OPA1,
PA2G4,
MYLK,
PAX6,
PDCD1,
PDE1C,
PDE2A,
PDK1,
SERPINF1,
NCAM1,
MYBPC2,
MGAT1,
MMP13,
KITLG,
MICE,
MKI67,
MME,
MMP3,
MMP8,
MPI,
MUC5AC,
MRC1,
MSMB,
MT3,
CYTB,
MUC1,
MUC4,
H3P10
Registered!
A rare familial cardiomyopathy characterized by left ventricular enlargement and/or reduced systolic function preceded or accompanied by significant conduction system disease and/or arrhythmias including bradyarrhythmias, supraventricular or ventricular arrhythmias. Disease onset is usually in early to mid-adulthood. Sudden cardiac death may occur and may be the presenting symptom. In some cases, it is associated with skeletal myopathy.