Behçet Disease
Watchlist
Retrieved
2022-04-26
Source
Trials
—
Genes
ERAP1,
IL10,
HLA-B,
STAT4,
KLRC4,
CCR1,
MEFV,
IL12A-AS1,
IL23R,
PSORS1C1,
CXCL8,
TLR4,
ICAM1,
UBAC2,
FAS,
IL12A,
ITGB2,
ITGAL,
AHR,
SERPINE1,
C4A,
APOA1,
APOB,
CAT,
MICA,
NOD2,
TNFRSF1A,
PSTPIP1,
CCR3,
MICB
ERAP1,
IL10,
HLA-B,
STAT4,
KLRC4,
CCR1,
MEFV,
IL12A-AS1,
IL23R,
PSORS1C1,
CXCL8,
TLR4,
ICAM1,
UBAC2,
FAS,
IL12A,
ITGB2,
ITGAL,
AHR,
SERPINE1,
C4A,
APOA1,
APOB,
CAT,
MICA,
NOD2,
TNFRSF1A,
PSTPIP1,
CCR3,
MICB,
KLRC4-KLRK1,
ADA2,
CCHCR1,
CDSN,
HLA-DRB9,
TFCP2L1,
HLA-C,
NOS3,
IL1A,
F5,
TNF,
HLA-A,
IL12RB2,
IL17A,
IL6,
WWC1,
IFNG,
IL19,
F2,
IL1B,
TNFAIP3,
IL2,
CTLA4,
MTHFR,
CCR5,
KIR3DL1,
TLR2,
CCL2,
IL23A,
HLA-DRB1,
VEGFA,
IL18,
VDR,
IL37,
GEM,
MMP9,
IL4,
ACE,
CRP,
IL12B,
IL1RN,
HSPD1,
IL33,
STAT3,
NLRP3,
MIR146A,
CD40,
LEP,
PTPN22,
JAK1,
MBL2,
ENO1,
BCL2,
KIR3DL2,
SUMO4,
NFKB1,
MIR155,
IL9,
ITGAX,
HSPA14,
GATA3,
KIDINS220,
IRF8,
CXCR2,
GSTM1,
HLA-G,
KIR2DS1,
HLA-DQA1,
TLR7,
ABCB1,
IL17F,
FCGR3A,
LTA,
CD28,
QPCT,
UBASH3B,
CSF2,
ATG5,
ADIPOQ,
SELL,
SLC11A1,
SOCS1,
SOAT1,
USO1,
TAP2,
IKBKG,
TAP1,
PIEZO1,
TG,
TGFB1,
TGFBR1,
TGFBR3,
THBD,
TNFRSF1B,
TNFSF4,
PTPN2,
KIR3DS1,
NOD1,
MVK,
LAMP1,
JAK2,
MIF,
MKI67,
SEC14L2,
ITGAM,
IL1R1,
IL22,
CXCL10,
CPQ,
NFKBIA,
IL15RA,
IL15,
NM,
NOS2,
TBC1D9,
KRAS,
NXF1,
MPO,
NAT2,
IFNA13,
GSTT1,
MIB1,
GAS6,
ERAP2,
FLNB,
FCN2,
ETS1,
TSLP,
CYP2C9,
CYP2C19,
TIRAP,
FCRL3,
CPB2,
RBM45,
IFNA2,
CEBPB,
MIR21,
CCDC180,
ANXA2,
ANXA1,
CXCR3,
CCR7,
IFNA1,
IL26,
HLA-DPB1,
CPVL,
HNRNPA2B1,
HLA-E,
TLR9,
LINC01193,
TNFSF12,
CDK5R1,
PROZ,
IL32,
GADL1,
TIMELESS,
SOCS3,
ARMH1,
CTDP1,
SCAF11,
ARHGEF2,
XPR1,
MBL3P,
CD83,
ENHO,
SLC9A3R2,
YIPF7,
PPIG,
IFNL2,
AIM2,
DAOA,
ROCK2,
GAL3ST1,
CCL4L2,
NAALADL2,
IL27,
ZEB2,
WDR1,
LRPPRC,
TNFSF13,
TP63,
CCL4L1,
IL17D,
HNRNPA1P10,
WNT3,
VWF,
POTEF,
DEFB4B,
CNTN5,
LINC-ROR,
LANCL1,
VTN,
VIP,
VEGFB,
UPK3B,
CST12P,
H3P13,
YWHAE,
DEFA1A3,
MIR146B,
DEFB104B,
WG,
ARHGEF5,
TAM,
MIR326,
PLA2G6,
TNFSF12-TNFSF13,
MIR301A,
MIR23A,
TLR8,
GEMIN2,
MIR185,
PIAS1,
MIR182,
RABEPK,
HT,
TNIP1,
CD274,
PANX1,
ATG10,
NDEL1,
POU2F3,
PDCD1LG2,
HAVCR1,
RNF39,
ARMC9,
DISC1,
IL17B,
PDCD4,
PYCARD,
NEIL1,
VKORC1,
FOXP3,
CASP14,
PADI1,
PDIA2,
CLEC7A,
TET2,
CASZ1,
PRPF40A,
BACH2,
NCOA5,
TBX21,
SEMA6A,
TRIM39,
AICDA,
CD209,
IL20,
KIAA1109,
TUBA1C,
ASXL1,
KLRK1,
RETN,
ANP32B,
PROCR,
SLC35A1,
CXCL13,
TNFSF13B,
DEFB104A,
TRAF3IP2,
CPLX1,
UTS2,
PRSS21,
TYMS,
EBNA1BP2,
NLRP1,
CYCS,
HAVCR2,
KIR3DL3,
TNFRSF13C,
CLEC16A,
TREM1,
KRT20,
CDCA5,
DICER1,
INTS4,
SIRT1,
IRAK4,
SF3B1,
ZNF804A,
PADI4,
ADO,
VCAM1,
PSMD7,
TYK2,
ELANE,
FLNA,
FOXO1,
FCGR3B,
FCGR2A,
F10,
F9,
ETFB,
ESR1,
EREG,
EGF,
FUT2,
DHCR7,
DEFB4A,
DEFB1,
DEFA1,
CYP27B1,
CYP24A1,
CYP2B6,
CYP1A1,
CX3CR1,
FSHMD1A,
GATM,
TXK,
HLA-DQB1,
IL2RA,
IFI16,
HTR2C,
HSPA6,
HSPA4,
HNRNPA1,
HMOX1,
HMGB1,
HLA-F,
NRG1,
GCHFR,
HFE,
HBB,
H2AX,
GZMB,
CXCL1,
GRIA2,
GP2,
GLI3,
GLB1,
CTSG,
CCN2,
CSF3,
FASLG,
C3AR1,
BTK,
BLK,
AVP,
ATP4A,
ATP12A,
ATF3,
ARSA,
AREG,
APOH,
CSF1,
APOE,
ANXA5,
AMH,
ALB,
AKT1,
AIF1,
ADARB1,
ADA,
ACTB,
C4BPA,
C4BPB,
CA4,
CALR,
CR2,
CORT,
CCR6,
CCR4,
CISH,
CEBPD,
CDKN2D,
CDKN2A,
CD69,
CD40LG,
MS4A1,
CD14,
RUNX1,
CASP9,
CASP8,
CASP3,
CASP1,
CAPS,
CAMP,
IL2RB,
IL4R,
IL6ST,
SAG,
CXCL5,
CXCL6,
CCL20,
CCL13,
CCL11,
CCL5,
CCL4,
CCL3,
SAT1,
SAA1,
EIF2AK2,
RORC,
ROCK1,
REG1A,
REL,
ACLY,
PSMB8,
PRTN3,
PROS1,
PROC,
CX3CL1,
SELE,
SELPLG,
SLC6A4,
HSP90B2P,
TRAF5,
TPI1,
TP53,
TLR1,
TIMP2,
TGM2,
TEP1,
TRG,
TRD,
TRBV20OR9-2,
TRIM21,
SPP1,
SPG7,
SOD2,
SOD1,
SLC22A5,
SLC22A4,
SLC25A1,
PRL,
MAPK3,
CXCR1,
KLRD1,
MAFD2,
LYZ,
LIMK2,
LIG4,
LGALS3,
LBR,
STMN1,
RPSA,
LAMC2,
KLRC2,
MAPK1,
KLRC1,
KIR2DL4,
ITGB3,
ITGA2,
IRF5,
IRF1,
IRAK1,
IL12RB1,
IL11,
MCAM,
CIITA,
MMP2,
MMP12,
PRKCQ,
PON1,
POMC,
PLA2G2A,
PLA2G1B,
SERPINA1,
PF4,
PDGFRL,
PDCD1,
PAPPA,
PAFAH1B1,
P4HB,
ORM2,
NTRK1,
NGF,
NEFM,
NDUFB2,
MRC1,
MNAT1,
H3P28
Drugs
Adalimumab
(
CYLTEZO,
AMGEVITA,
AMSPARITY,
HALIMATOZ,
HEFIYA,
HULIO,
HUMIRA,
HYRIMOZ,
KROMEYA,
IDACIO,
IMRALDI
),
Apremilast
(
OTEZLA
),
Colchicine
(
COLCHICINE HOUDE,
COLCHIMAX,
COLCRYS
)
Adalimumab
(
CYLTEZO,
AMGEVITA,
AMSPARITY,
HALIMATOZ,
HEFIYA,
HULIO,
HUMIRA,
HYRIMOZ,
KROMEYA,
IDACIO,
IMRALDI
),
Apremilast
(
OTEZLA
),
Colchicine
(
COLCHICINE HOUDE,
COLCHIMAX,
COLCRYS
),
Gevokizumab,
Recombinant human residue 41 glutamic acid to glutamine variant of Interferon-alfa-2b,
Recombinant humanised anti-human interleukin-1 beta monoclonal antibody
Registered!
Behçet disease leads to swelling of the blood vessels and affects multiple organs throughout the body. Symptoms generally begin when individuals are in their 20s or 30s, but may occur at any age. Symptoms may include ulcers affecting the mouth and genitals, various skin lesions, and swelling of the membranes affecting the eyes. In some people, symptoms include arthritis (swollen, painful, stiff joints), skin problems, and inflammation of the digestive tract, brain, and spinal cord. Symptoms of Behçet disease may be active and then become inactive, but they never completely go away. In some cases, Behçet disease may lead to vision loss and neurological problems. The exact cause of Behçet disease is unknown, but it is thought to be due to a combination of genetic, immune, and environmental factors. Diagnosis is based on the symptoms and clinical examination. Diagnostic guidelines have been published. Treatment is focused on managing the symptoms and includes steroids and drugs that suppress the immune system.