Aortic Aneurysm, Familial Abdominal, 2

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Retrieved
2019-09-22
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Trials
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For a phenotypic description and a discussion of genetic heterogeneity of familial abdominal aortic aneurysm, see AAA1 (100070).

Mapping

Shibamura et al. (2004) performed a whole-genome scan of AAA using affected relative-pair (ARP) linkage analysis that included covariates to allow for genetic heterogeneity. They identified a region on chromosome 4 with a lod score of 3.73 (P = 0.0012) near marker D4S1644 (4q31) when including sex and the number of affected first-degree relatives of the proband as covariates.