Lelis Syndrome

Lelis syndrome is characterised by the association of ectodermal dysplasia (hypotrichosis and hypohidrosis) with acanthosis nigricans.

Epidemiology

So far, only eight cases have been described in the literature.

Clinical description

Other clinical features may include palmoplantar hyperkeratosis, nail dystrophy, intellectual deficit and hypodontia.

Genetic counseling

Transmission is autosomal recessive.