Benadryl Challenge
The Benadryl challenge is an internet challenge which emerged in 2020, and revolves around the deliberate consumption, abuse and overdose of the antihistamine medicine diphenhydramine, commonly sold in the United States under the brand name Benadryl.[1] The challenge, which spread via the social media platform TikTok, instructs participants to film themselves consuming large doses of Benadryl for the purpose of 'tripping', or hallucinating.
The recreational use of diphenhydramine and its associated abuse and addiction is well-reported in medical literature, and overdoses are treatable with correct intervention. In addition, its psychoactive effects at high dosages, which are a symptom of anticholinergic poisoning, are also well documented. In severe cases, the overdose of diphenhydramine and other anticholinergic medicines can lead to a phenomenon referred to as an 'anticholinergic toxidrome', which can affect organ systems throughout the body, including the nervous system and cardiovascular system.
Numerous authorities have advised against the challenge, as deliberate overconsumption of diphenhydramine can lead to adverse effects, including confusion, delirium, psychosis, organ damage, hyperthermia, convulsions, coma and death, among others. On September 24, 2020, the FDA formally released a statement advising parents and medical practitioners to be aware of the challenge's prevalence and its risks.
Several participants have been hospitalised as a result of the challenge, including three teenagers admitted to the Cook Children's Medical Center after consuming at least 14 diphenhydramine tablets, and 15-year-old Chloe Marie Phillips, an Oklahoma teen that died from an overdose after attempting to take part.
See also
- Consumption of Tide Pods
Notes
- 1.^ In other countries, products sold under the brand name Benadryl may contain a different antihistamine; in the United Kingdom, this is the second-generation antihistamines acrivastine or cetirizine.