Felty Syndrome

Blendis et al. (1976) described a mother and her son and daughter with Felty syndrome (rheumatoid arthritis, splenomegaly and neutropenia). Another sib had rheumatoid arthritis alone. Felty syndrome seems to be confined mainly to white males (Termini et al., 1979; Lewis, 1980). The low frequency in blacks may be related to the low frequency of HLA-DRw4, which shows association with Felty syndrome.

Ditzel et al. (2000) identified eukaryotic elongation factor 1A-1 (EEF1A1; 130590) as an autoantibody in 66% of patients with Felty syndrome.