Mantle Cell Lymphoma

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Retrieved

2022-04-26

Source

Gard

Trials

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Genes

ATM, CCND1, PIK3CD, MTOR, NOTCH1, WNT3, WNT10A, GSK3B, UBR5, CTNNB1, ARHGAP29, EIF4EBP1, EIF4E, BIRC3, AK1, SYK, MYC, BCL2, C11orf65, BTK, TP53, SOX11, IGH, KRT20, MS4A1, MME, CCND2, MDM2, CDKN2A, FCER2, MCL1, CLEC4D, PIK3CG, PIK3CB, FH, EZH2, PIK3CA, SMUG1, BCL2L11, STAT3, HSP90AA1, PMAIP1, AICDA, CDK4, BMI1, PSMD9, PARP1, TMED7-TICAM2, RTEL1, CD19, TMED7, H3P23, IFI27, IGHV3-69-1, PRMT5, CDR3, COMMD3-BMI1, BCL6, DCTN6, CHEK1, TICAM2, XPO1, ZNRD2, CD200, LOC102723407, BACH2, ATR, MALT1, IL10, IGHV3OR16-7, LOC102724971, RB1, HILPDA, CD5, LEF1, IBTK, RAD1, IGK, CCND3, PAX5, IGF1, MIR16-1, HTC2, TNFRSF10A, VEGFA, MIR155, AKT1, MIR17, CDKN2B, CDKN1B, SLC29A1, TNF, TCL1A, MIR17HG, TERT, ZEB1, CD40LG, H3P9, HDAC6, AURKB, HACD1, WNT5A, CXCR4, HAGLROS, IGF2BP3, USP2, SORBS1, MRPL28, SOCS3, CAP1, CFDP1, ABCG2, KMT2D, APOBEC3B, TCL1B, LOC110806263, BCL10, DLEU2, CD83, ARID1A, PDZK1IP1, CDC42BPA, CNTNAP1, TNFSF10, LOC105379528, KLF4, PDE7B, TNFSF13B, TP53INP1, E2F8, MIR615, CD276, DOHH, ARHGAP24, ATRIP, CARD11, MIR506, GLIS2, DNER, BMS1P20, RGS18, MIR18B, BTLA, CCDC50, CBLL2, MIR223, LINC01139, SLC35B2, MALAT1, LOC390714, MIR15A, MUL1, MIR92B, SUB1, HPGDS, PIM2, TPX2, BRD4, SUZ12, PRAME, ROR1-AS1, MLSM7, FBXO10, GREM1, MIR15B, NXT1, GAS5, GEMIN4, CRBN, IGLL5, MS4A4A, PAG1, PBK, WEE1, MIB1, IL21, MEF2B, ADAM10, CCL19, LAT2, GNAZ, EIF4G2, CTTN, ESR2, EZH1, FASN, FCGR3A, FOXO1, FOXO3, FMOD, FUT1, GATA6, GLI1, CXCR3, LNPEP, GPT, GSTP1, HDAC1, HSPA5, IGF2, IGLV@, IL2, IL4, IL12A, IL12B, TNFRSF9, LAIR1, ATN1, DPP4, DNMT1, DCK, ALOX5, ANXA1, AR, BAX, BIK, PRDM1, BMP7, CASP8, RUNX2, CCNB1, CCNG1, CD28, CD36, CD40, CD70, CD74, CDK6, CDK7, CDKN1A, CTSC, CCR7, CNR1, CRP, CSF1R, CTAA1, LCK, LTB, VCP, SMARCA1, PTK2, NECTIN2, RAC1, RANGAP1, RGS13, SCN10A, CCL3, SDC1, CXCL12, SETMAR, SHH, SLC7A4, SOX4, MDM4, SOX12, ST14, STAT1, STAT5B, AURKA, MAP3K7, TAL1, TRBV20OR9-2, TGM2, TOP2A, TP73, NR2C2, PSMD2, MAPK8, PRELP, PPP2R1B, MIP, MKI67, MLH1, KMT2A, MMP9, MRC1, MSH2, MSX1, MT1A, MTAP, MYCN, NCL, NEDD8, NME1, NOTCH2, NTRK1, PRDX1, PRKN, SERPINA5, PDE3B, PECAM1, SERPINB6, PIM1, PLSCR1, PMS1, H3P10

Drugs

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Mantle cell lymphoma (MCL) belongs to a group of diseases known as non-Hodgkin’s lymphomas (NHL). NHL's are cancers that affect the the lymphatic system (part of the immune system). In MCL, there are cancerous B-cells (a type of immune system cell). The cancerous B-cells are within a region of the lymph node known as the mantle zone. Although MCLs are slow-growing cancers, the cancer is usually widespread by the time it is diagnosed. In these situations, treatment must be intensive since MCL can become life threatening within a short period of time. MCL accounts for 6% of all NHL's and is mostly found in males during their early 60s.