Earlobe Crease

Frank (1973) and Lichstein et al. (1974) suggested that a diagonal crease of the earlobe is an indication of increased risk of coronary heart disease. Whether the trait is mendelian is not clear. The frequency of the trait seems to increase with the age of the cohort. Elliot (1983) confirmed an association between earlobe crease and coronary artery disease independent of patient age. On the other hand, Gral and Thornburg (1983) could find no statistically significant correlation. See 130650 and 186350 for syndromes in which an earlobe crease is observed.