Large-Cell Lymphoma

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Retrieved

2021-01-18

Source

Wikipedia

Trials

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Genes

BCL2, BCL6, HLA-DRB1, CHEK2, RAD54B, BCL10, FPGS, RAD54L, EPHX1, MTHFR, CYP2E1, CSF3, CSF2, IFNA2, TYMS, PRF1, CBS, CASP10, TFRC, SHMT1, BHMT, TNFRSF8, ALK, PDLIM7, PTPRC, NCAM1, ADA, BRAF, CHP1, NDRG2, H3P19, TNF, LOC102724971, LOC102723407, TP53, SLC35B2, NRSN1, ATAD1, VIM, TPPP, RTEL1, RFXANK, SCAPER, IGHV3-52, HDAC9, SIRPB1, CCT4, TMED2, SOX10, STAT3, MYC, SOD2, HSPA4, BTK, CASP3, CD9, CDKN2A, CLTA, ADAM3A, DCK, EZH2, NR3C1, GUCA1B, GUCY2D, HNMT, HSPA8, RNASEL, IFNB1, IGH, IL1B, IL4, CXCL8, IL10, IRF4, LIF, LMNB1, SERPINB2, PLG, RARA, H3P10

Drugs

Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus, Anti-CD123 IgG1 humanised monoclonal antibody conjugated to N1-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)-N6-((S)-1-(((S)-1-((3-((((S)-8-methoxy-6-oxo-11,12,12a,13-tetrahydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-9-yl)oxy)methyl)-5-((((S)-8-methoxy-6-oxo-12a,13-dihydro-6Hbenzo[5,6][1,4]diazepino[1,2-a]indol-9-yl)oxy)methyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)adipamide, haematopoietic stem cells and blood progenitors umbilical cord-derived expanded with (1R, 4R)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine dihydrobromide dihydrate

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The large-cell lymphomas have large cells. One classification system for lymphomas divides the diseases according to the size of the white blood cells that has turned cancerous. A large cell, in this context, has a diameter of 17 to 20 μm. Other groups of lymphomas in this system are the small-cell lymphomas and mixed-cell lymphomas.

Types

B cell

Diffuse large B-cell lymphoma is the most common of the large-cell lymphomas. MeSH now classifies the phrase "large-cell lymphoma" under "Diffuse large B cell lymphoma".

Many other B-cell lymphomas feature large cells:

Angiocentric lymphoma
Burkitt's lymphoma
Follicular large-cell lymphoma
Immunoblastic lymphoma
Intravascular large-cell lymphoma
Primary mediastinal B-cell lymphoma
T-cell–rich B-cell lymphoma
Primary splenic lymphoma (rare)
Primary central nervous system lymphomas, which are often diffuse large-B-cell lymphomas

Activated B-Cell Diffuse Large B-Cell Lymphoma, or ABC-DLBCL, is believed to be caused by aberrant activation of a critical intracellular pathway. This intracellular signaling pathway involved in B-cell activation and proliferation stays constantly activated, driving lymphocytes to proliferate continuously. The inhibition of this pathway can be induced by a drug known as NEMO Binding Domain, or NBD, a peptide causing increased cell death of malignant lymphocytes.

T cell

Less commonly, a large-cell lymphoma may feature T cells. Anaplastic large-cell lymphoma is an example of a large-cell lymphoma that involves T cells. Of the large-cell T-cell lymphomas, it has the best prognosis.