Glioma Susceptibility 2

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Retrieved

2019-09-22

Source

Omim

Trials

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Genes

TP53, IDH1, CDKN2B, PTEN, NBN, SPP1, BRAF, ATM, CDKN2A, NF1, HRAS, RTEL1, CCDC26, ACVR1, EGFR, PHLDB1, MGMT, MDM2, GDNF, ATRX, PTGS2, BMI1, TNFSF10, CHI3L1, XRCC1, H3-3A, TNF, ERBB2, FGF2, PIK3CA

TP53, IDH1, CDKN2B, PTEN, NBN, SPP1, BRAF, ATM, CDKN2A, NF1, HRAS, RTEL1, CCDC26, ACVR1, EGFR, PHLDB1, MGMT, MDM2, GDNF, ATRX, PTGS2, BMI1, TNFSF10, CHI3L1, XRCC1, H3-3A, TNF, ERBB2, FGF2, PIK3CA, TERT, GSTP1, SLC5A5, ROS1, RAF1, PLK1, HLA-C, FBXW7, STMN1, TOP2A, POT1, TFRC, KLF6, CLCN3, MDK, FGFR1, NTRK1, CIC, SOD1, CAT, XBP1, HLA-A, HLA-B, MYB, PPM1D, ATP1B2, FUBP1, APC, CDKN2C, MSH2, PIK3R1, ALK, HMGN5, H3C2, NTRK3, DMBT1, APOD, CLCN2, FTH1, ATR, PMS2, SUZ12, QKI, GJA1, DMXL1, PSD3, IFNG, NTRK2, CCR4, MET, IL12A, IL12B, FAM107A, XAF1, BRCA2, MYLK, MYBL1, CTSB, STAG2, TNC, MMP2, TRIM29, CLCN5, BCAN, AKT2, BIRC5, HMGB1, ANGPT2, CAV1, SPHK1, BAD, EPOR, SIRT2, CSF1, CXCR3, LGALS3, MKI67, CD80, ST6GAL1, YEATS4, IL7, AREG, F2, SH3GL1, SLC6A3, MDM4, CAV2, ATG7, PCMT1, BDKRB2, LRIG1, CDKN2B-AS1, RAB27A, ETFA, VTI1A, CHEK2, STN1, AKAP6, AKT3, STK38L, SMYD3, TREH, MAML2, GLI3, C2orf80, SLC16A8, HIF1A, GDE1, ZBTB16, EPHB2, LRP5, ABCB1, MALAT1, ERCC1, ERCC2, CXCR4, IDH2, DBT, HGF, PDGFRA, CD44, TRAF5, NRP1, NFE2L2, EZH2, PIK3CB, MTDH, PIK3CD, SERPINE1, EGF, OLIG2, MIR155, SLC25A24, TNFRSF12A, VEGFA, E2F1, MMP9, PLAU, MIR145, POLR2A, MIR21, ACOT11, PKM, MAPK14, DNMT1, XRCC3, GSC, CD274, YAP1, PIK3CG, POU5F1, MIR221, PCNA, CDK4, CDK2, CTNNB1, MCL1, NOTCH1, HPGDS, MIR182, GOLGA3, MAPK1, BDNF, TBC1D9, SPARC, MTOR, KDR, LGI1, FAS, AQP4, COX2, IL13RA2, STAT3, IL13, IL10, MIR34A, POU5F1P3, CXCL8, MYC, RAC1, IL6, CCND1, BCL2, FOXM1, SOX9, HEATR3, SOX2, RTEL1-TNFRSF6B, H3P10, MEG3, MMP14, LOC110806263, ACTB, MTCO2P12, RNU6-1318P, CXCL12, MIR4300HG, GLI1, HOTAIR, POLR3B, RAVER2, PARP1, SHANK2, ABCG2, GFAP, ABCC1, AKT1, KIF26B, GOLPH3, POU5F1P4, TGFB2, CASP3, TSPO, PTN, PTK2, NES, TGFB1, IL4R, LMF1, LRRC31, IGFBP2, H3-3B, CASP8, SLC35A3, DKK3, MAP2K7, CCK, IGF1, PPP1R2C, PROM1, IFNB1, F3, MAPK8, MAPK3, IL1B, NEAT1, PVT1, IL4, RHBDF1, ZEB1, IL2, SIRT1, LRRC4, MIR107, COMMD3-BMI1, IL24, CSF2, HMGA2, VIM, BAX, MIR126, NFKB1, CRK, MIR205, CDK6, MIR146B, CDKN1A, MIR200B, HSPB1, CDKN1B, EPHA2, GSTT1, RNF19A, HOXA11-AS, EFEMP1, LGALS1, CCL2, POLDIP2, PDGFA, TICAM2, AIMP2, PDGFRB, AHSA1, MIR203A, HSPA5, UCA1, CRNDE, NOTCH2, MIR139, GABPA, MIR10B, TMED7, PPARG, FASLG, SETD2, SALL4, PAX3, PSMD9, GRAP2, JAG1, PTPN11, TMED7-TICAM2, FLT1, FN1, COL18A1, BECN1, CASC2, FOXO1, NGF, FGFR3, GLB1, FOXO3, HSPB3, SLCO6A1, SDC1, IGF2, S100B, CASP9, MIR200A, HSPB2, HPSE, MIR137, TWIST1, SMUG1, MIR132, ROCK1, MIR29A, POSTN, IFI27, CTSL, MIR130B, PDPN, DCTN6, ATF5, GSTK1, ZNRD2, THBS1, H3P23, CCN1, IL1A, TIGAR, PTTG1, XRCC6P5, MIR195, MIR184, XIAP, MIR183, ZEB2, VDR, IGF1R, TLR9, STAT1, FOXD2-AS1, PRKCA, TIMP2, CDC42, GAS5, TCF4, CYTOR, BMP4, TEK, BSG, ING4, AURKB, SP1, PDGFB, MIR106A, PBK, ACKR3, HSPA4, FZD7, MIR140, SLIT2, WNT5A, CREB1, MIR122, MIR15B, SMAD2, KLF4, ANXA5, PECAM1, MIR675, MIR451A, TF, TLR4, MSH6, GORASP1, MIR338, ITGAV, GDF15, PTBP1, FGF13, NCL, GLI2, TGM2, PTPRZ1, WNK1, MIR342, KLRK1, HDAC6, KLRC4-KLRK1, SNAI1, SLC2A1, GAS1, KMT2A, ILK, TP73-AS1, RELA, SRPK1, CD163, LILRB1, AQP1, MTHFR, NLGN3, LRIG2, AHR, CXCL10, SYT1, ADAM17, DICER1, AXL, MIR497, ALB, TAZ, MSH3, GLIPR1, FOXP1, CCNE1, WLS, MIR20A, WWTR1, EGR1, MIR185, MIR186, SPINT2, MIR19A, KHDRBS1, MIR23B, MIR204, MIR210, MIR214, MIR222, HAVCR2, BEX2, PLG, OSM, FOXP3, NDRG1, PRDX1, MIR142, MIR141, DSC3, VCAN, XRCC4, LDHA, ZEB1-AS1, ZFP36, PGAM1, PEG3, DCN, TFPI2, ICAM1, MIR146A, CD34, PRKAA2, HDGF, MIR98, MIR320A, PRKDC, NOS2, BCL2L12, ETS1, MIR30A, PRKCB, FABP7, ERCC4, NGFR, MIR93, EPO, PTK2B, CDK1, SEPTIN7, MIR326, PRKAA1, LRP1, ITGA3, RASSF1, HDAC1, PRMT5, PSIP1, SND1, CXCR6, JAK2, ITGB1, H2AX, ITGA5, MMP3, NOB1, ZHX2, UBD, TACC3, MFAP1, MARCKS, ABCB6, SIRT6, SNHG1, PPP1R13L, KNG1, GAB2, KRAS, MECP2, HLA-DRB1, TRIM28, BRD4, HDAC4, EGFL7, IFNA1, ANGPTL2, WWOX, IFNA13, G0S2, HSP90AA1, IL17A, RECK, CUX1, RB1, DACH1, MIR424, DCX, TERC, TIMM8A, DHCR24, PDCD1, PVR, PCBP2, PBX3, PAX6, TCF7L2, PDIK1L, TCF3, E2F3, ECT2, LGR5, RAD51, TAC1, LINC00461, SLC22A18, TRAF6, PRRT2, MIR584, ABCC3, TGFA, MIR377, MIR106B, TLR2, PRKAB1, CDC25A, MIR27A, PRKCI, MIR23A, ZFAS1, MIR215, MIR211, VHL, MIR133B, CLDN5, TIMP1, MIR375, MIR152, MIR149, XIST, MIR136, MIR134, MIR125A, MIR373, CCN2, CTLA4, MIR10A, CX3CR1, RIPK1, CD70, SHH, SATB1, S100A4, NFATC2, SOAT1, DHDDS, SLC12A9, ROBO1, SNHG16, MSC, AICDA, SMARCA4, NEDD4, MARCKSL1, CPEB1, SNAI2, FRK, FOXD1, NDRG2, FLT3LG, FOLH1, CHPT1, S100A1, SESN2, FADD, AJAP1, EPAS1, SST, APRT, ESR2, ASIC2, MIR92B, NOTCH3, ADAM9, TNFRSF10B, MAGED4, APEX1, ESR1, CCL5, SDCBP, THY1, S100A9, TP73, RPSA, SFRP1, TNFRSF1B, ITSN1, STAT5B, PTHLH, SIX1, RALBP1, RBL2, KIT, STAT6, STK11, TAT, CNTN2, UPF1, RFX1, L1CAM, RSU1, FSCN1, TFAM, TFAP2A, PTPN1, UBE2C, TRIM31, SSTR4, TGFBI, AURKA, IKBKE, TTC4, IL18R1, NEK2, PER2, NF2, HDAC3, IQGAP1, CD46, PTPRU, TNFRSF4, TNFRSF10C, NOS1, ACTR2, NAMPT, EBI3, NRAS, NEFL, NELL1, NEDD9, SQSTM1, MYH2, BCL10, PDCD5, MTAP, MELK, MLH1, HDAC9, COX5A, MMP1, MSI1, MRC1, KIF23, CLOCK, YBX1, MAP2, PSMG1, SERPINF1, TXN, EZR, LCN2, PLP2, TRPV1, VWF, WNT1, WT1, IGF2BP3, MMP7, LIF, LIG4, BTG2, CDK14, LOX, MAOB, FOSL1, CIB1, PDK1, SLC7A5, MCRS1, AXIN2, BRAP, SERPINA3, SEMA3A, SMAD4, PAK4, P2RX7, SPRY2, KHSRP, WIF1, FOXA1, BNIP3, FAT1, PDXP, BTK, DANCR, FPR1, MIR429, MIR423, MARK4, MIR383, MIR382, MIR381, MIR378A, MIR374A, FOS, CALR, NGB, MIIP, FOXC1, ADGRL4, FGFR2, CAPG, MIR335, RUNX2, RUNX1, KLF9, GAPDH, BRCA1, LARP6, ROBO4, GRM3, ASL, ATP1A1, TET2, NR3C1, TRPM7, TUG1, CEP55, MIR504, TNFRSF19, SLC2A4RG, MIR524, MIR181D, MIR494, MIR491, MIR490, GLS, MIR489, MIR485, MIR410, GBP1, NANOG, SERPINH1, GSK3B, TET1, RBM45, E2F2, DUSP2, MIR15A, MIR150, ATN1, DPP4, MIR148A, COX8A, CPE, CPOX, DOCK1, FOXK1, CRP, CSF1R, MIR130A, TINCR, LINC00174, CYP1A1, MIRLET7B, CYP2B6, IRGM, LINC01194, MIR188, MIR200C, CFL1, CD151, MIR324, CPEB4, CD276, MAGED4B, CCND2, ERN1, MIR31, ERBB3, EPHB4, CD68, CTTN, CEBPB, WNT3A, MIR26B, PYGO2, CDH1, MIR224, MIR223, ELAVL1, MIR219A1, CEACAM5, MIR206, SNHG20, CYP19A1, GSTM1, IL2RB, DCTN4, TNFRSF9, SASH1, ADCYAP1R1, IL13RA1, ANXA2, CCL22, ANGPT1, OCLN, IL22, NOP53, SIRT3, MIR216B, EEF2K, IKBKB, MIR661, RGCC, DLL1, PDCD4, AGO2, SIGLEC7, IGFBP6, CBX7, HP, SNHG18, NUP62, GSTM3, SLC7A11, HSPA1B, HES1, ING1, HSPA1A, SPRY4-IT1, HK2, GTF2H1, MMRN1, ISG20, ADAM22, RND3, ADA2, DKK1, MIR599, MIR613, MIR622, NRG1, HCLS1, PTCSC3, GACAT3, UGT1A, UBE2N, SKP2, WNT7B, TYMS, SHMT2, XPO1, YY1, CCAT1, MIR25, ZAP70, SDC2, ZFX, HOTTIP, MIR1908, MIR1301, TRPC6, TRPC1, MIR27B, BCAR4, MICA, MIR296, TRP-AGG2-6, UCN, WNT7A, MIR17, MIR127, MIR301A, WSPAR, MIR16-1, XRCC5, MIR181A2, PANTR1, GHET1, MIR181C, MIR129-2, MIR193A, SIM2, UGT8, BLACAT1, VEGFC, LINC02605, HOTAIRM1, SH3GL2, H3P5, USP1, UQCRFS1, LINC00958, MIR143, MIR18A, SLC22A3, MIR30B, SOX4, MIR638, TEP1, MIR650, SNHG5, OIP5-AS1, MIR452, ACOD1, MIR433, MIR363, MIR449A, MIR454, NR2F2, MIR770, SOX10, MIR448, MIR376B, MIR637, TRA, STC1, SYP, SUV39H1, SULT2A1, SNHG6, MIR539, MIR421, HAS2-AS1, TCF12, MIR592, STAT5A, MIR193B, MIR495, MIR634, SSTR2, MIR4435-2HG, MIR384, SLC8A2, MIR876, SMN1, MIR1231, MIR1294, SMARCA1, MIR1236, MIR17HG, MIR96, TPM3, SLC12A2, MIR95, MIR33A, TPT1, MIR32, SLC9A1, MIR30E, SMN2, MIR328, MIR1275, MIR936, SOD3, MIR361, HCG11, MIR374B, TGFBR2, MIR372, THBS2, CD24, MIR367, SNCA, MIR346, MIR940, MIR340, NR2E1, KLF8, AGPS, LINC01116, PIEZO1, DLL4, ELMO1, SV2A, KIF14, MVP, SCO2, PPIL3, HDAC5, FRAT1, CAB39, ACSL5, NLK, SMC4, MPC1, RNF138, KIF20A, HIPK3, TRAP1, TRPV2, ZMYND10, PHF20, KEAP1, FBLIM1, NCR3LG1, RMDN3, ADGRG1, CTNNBIP1, PNO1, SLC9A3R1, RAD18, SPHK2, PANX2, NTN1, POLE4, METTL3, ARHGAP15, NSUN5, URGCP, NLRP2, TMEM59, PTGES, CXCL14, SOX6, CDCA7L, BATF3, ZNF654, NDUFA13, RNF41, MPHOSPH6, ASCC1, SRRM2, DLL3, POLD3, CBX5, KDM5B, MTHFD2, GJB6, SYNM, USP22, FGL2, SUB1, MPRIP, FERMT2, SLC27A3, KDM6B, PEG10, RIPK3, PHLPP2, KDM1A, PTP4A3, CBX3, CADM1, CAMKK2, IL17RA, SEMA3C, F11R, TNIP1, DELEC1, ADGRE2, RACK1, NDC80, IFITM3, TMEM97, RBMS3, CACYBP, IGF2BP1, GREM1, LATS2, MYCBP, PHGDH, TRIM3, NOC2L, PHF19, ARHGEF26, CHD5, PIWIL1, PAK5, MTA2, CREB3L1, FOXR2, CD109, ATRN, LRIG3, PIK3R3, PARK7, VASN, BHLHE40, MIR155HG, DENR, MKNK1, NLRP3, UCN3, AZIN2, EGLN3, TP53INP1, PEA15, FOXQ1, TRADD, MBTPS1, TNFSF12, ULK1, PIWIL4, PWAR1, MAGI3, MACC1, SEMA3B, USP7, GADL1, LINC01139, SNHG15, HOXA-AS2, CAVIN1, ADGRF1, IL27, GLIPR2, CTAG1A, SPDYA, LGI3, SPAAR, MIA, MLRL, LINC00599, LZTR1, RDH10, ATP23, IL33, GATAD2B, ADAM23, IER3, MAPKAP1, P2RY12, ARHGEF7, HHIP, IL21, CXCL16, MBD2, CADM3, POLD4, PKD2L1, SEMA5A, SLC7A7, DIRAS3, NMI, LATS1, INA, AIFM1, ANKRD36B, MIB1, LPAR2, MMP28, SLC52A2, SHCBP1, BRMS1L, DIXDC1, CD164, TSPYL5, TNFRSF11A, SNHG12, ORAI1, TNFRSF10D, MAK16, ECRG4, TNFRSF10A, FER1L4, TRIM24, HSDL2, MINDY4, ZIC4, NUF2, NRP2, ARHGAP24, TRIM11, NR1I2, NAT2, H3P40, CXCL9, PIN1, PKD2, EMP2, HOXC10, PLAUR, EMP1, RHOA, ARF6, HOXC6, PLD1, MT1JP, HOXB3, PLOD2, ARAF, PLXNB3, CCR5, PITX1, SLC25A3, AQP9, FASN, ENG, HSP90AA2P, HSPA8, HSF1, ACSL4, ATF4, PER1, CDKN1C, ASPA, PFKFB4, PGK1, MUC1, AGFG1, HOXD9, MTRR, CCR6, CNR1, FKBP5, ANXA6, CRYAB, CSF3, CSK, AMBP, CST6, CD200, MAP2K1, ALDH1A3, CTAG1B, CTBP1, PRNP, CTSD, KCNMA1, PROX1, HMOX1, ANXA1, ANXA7, MT1E, HOXA@, CNTFR, POLD1, COL3A1, HOXA9, FEN1, COL4A3, EFNB2, MSN, PPARA, EFNA1, COL11A2, PPIA, KCNA5, FGF1, CP, CDK7, HSPG2, FANCD2, CD2, CALM2, IL2RA, CALM1, CALD1, P4HA1, P4HB, PEBP1, CALCR, NFKBIA, DDR1, PAEP, CA9, CA2, ERCC5, VPS51, CALM3, CAMK2B, HTC2, CCNH, NT5E, IMPA1, EPHA5, NTSR1, NUP98, IDO1, OPA1, RUNX3, NOVA1, IL18, CASP1, CCNG2, IL16, IL15, NME1, RBPJ, IGFBP7, CD86, EPHA3, ADGRE5, BCL2L1, EPHA1, MYCN, CDC20, MYBPH, CDC25C, CDH2, F2R, CDH13, ITGB3, F2RL1, PCDH8, PCDH9, MXI1, BCL3, IRS1, BCL6, KLF5, INSR, NFATC1, IGFBP3, IGFBP1, CD40, BTF3, BRS3, IRF7, CD40LG, IRF3, BMP7, ID2, ETV4, BGN, HMMR, CCNB1, LPL, MGP, CYP17A1, GRIN2B, RASGRF1, MCM2, RARB, ACE, HIC1, DCT, FOSL2, RAP2A, FOSB, RAB27B, ADRA1A, RANBP2, HK1, GRIA1, FLT4, GH1, ACTL6A, ADRA2B, ADRB2, HLA-E, ADM, DUSP4, GALNT2, LAMC2, TRIM27, FUS, ADARB1, REST, LGALS9, MEF2D, GSN, RELB, HAS2, REG1A, G6PD, HELLS, RDX, MEN1, LASP1, GRM1, FOXG1, CFH, XRCC6, DUSP1, HFE, GPX1, FUT4, SMAD3, SCD, MMP12, GPR42, PTX3, PTPRZ2, EDNRA, SAI1, PTPN2, PXN, DNMT3A, GLO1, KIF2A, PTPN3, SMAD7, DECR1, PSMB4, ACAT1, AEBP1, MXD1, TYMP, PSEN1, PSAP, DDX5, CCL20, RAB1A, PSEN2, DVL2, RAB5A, CCL8, GLUD2, AFAP1-AS1, ACRBP, MARCHF8, DIRAS1, EPHA4, DNM1, SNORD35B, RCAN1, DRD5, PCGF1, SLC29A1, DTX3L, PAQR3, DKC1, RMDN2, SPZ1, CCNY, TMEM167A, DNM2, DACT2, ADGRE3, PAQR7, CITED4, ANO6, KDM2B, MLKL, ENO1, PPP1R9B, LGI4, ZNF296, SLFN5, SLC5A8, CADM4, FMR1NB, DNMT3B, TET3, DPEP1, SLC39A11, PAXIP1-AS1, ZGPAT, PRSS55, SLC26A3, LNX1, PEBP4, SGMS2, LINC00689, PLEKHA8, SKA1, AGAP2, SNORD14E, ATG4C, ZFP42, LACTB, EEF1G, EDN1, MCM3AP-AS1, LINC00313, FAM83F, FAM168B, SLC52A3, TMEM18, SLC46A1, DYRK1A, EFNB3, VPS37A, EIF4E, EGLN2, EIF4EBP2, MEGF10, CMPK2, SERPINB1, IKBIP, THEM4, ANTXR2, LRG1, IL22RA2, KIR3DL3, PRAP1, UHRF2, H4-16, PHC1, RAB42, ATG4A, LGMNP1, EDNRB, JDP2, TSACC, CYGB, TMEM71, PASD1, AJUBA, E2F7, EMX2, EN2, ZIC5, RHPN2, SNORD14D, OR2AG1, SNORD14C, HBEGF, MIB2, CEP128, RBM17, DSPP, ATG4D, LINC00052, TTBK2, LINC00526, EMP3, UNC5A, UPRT, NLRP12, ORMDL3, ST7-AS1, DVL1, NAPRT, GAB3, NAF1, ELF4, PCED1B, STARD13, ELK1, ELK4, S100A16, SPOCD1, ZBTB46, LINC00473, DYNLL2, EEF1B2P2, MAP1LC3B, PHYHIPL, FXN, PRDM13, FLNB, KMT2C, NLRC4, ENOPH1, SRPRB, FLNC, FLOT2, PTBP2, FMOD, GATAD1, SCUBE2, KIAA1549, TSHZ3, CFAP97, PCDH10, SEMA6A, FPGS, RPTOR, GPR158, MTA3, FPR2, REXO1, TRPV4, PBOV1, TGIF2, NOD2, FHL3, CDH22, VEGFD, SIL1, ARHGAP9, COP1, NSD1, FBRS, FKBP4, ARHGEF28, TNMD, FLG, SMOC1, SAMSN1, FOXL1, PRSS22, ERVK-6, HEATR6, PIEZO2, FOXC2, PROK2, FOXD2, PLEKHG5, SCYL1, MAP3K21, FTH1P3, LRRC8A, GSDMC, TEX11, PCDHGA11, SLC50A1, GJB2, SULF2, ACSS2, GCLC, GCLM, CENPJ, UBAP2, ADCY10, CACNA2D3, PRR11, AGK, HHAT, WDR11, GLDC, GLP1R, GLUD1, SYBU, CHD7, MMP26, DIABLO, KAT2A, GAB1, TTYH1, GAST, VANGL2, SMURF1, FZD2, RTN4, GOPC, PNPLA2, SLC17A7, SLC37A4, GAD1, GBP3, LHX9, PMEPA1, CA10, SEMA3G, GAP43, LGALS14, GAS6, GATA2, SLAMF8, GATA6, FHL2, TMPRSS3, GPC5, FGF9, DDX59, EXT1, MED25, ST6GALNAC5, SPRY4, NUAK2, NQO1, KAZALD1, TRIM8, NDEL1, EZH1, CLPTM1L, ZNF436, CMIP, F10, PDCD1LG2, ACSL1, ACSL3, SPHKAP, TRIM45, ORAI2, FHOD3, CTC1, MECOM, RASSF5, SOX7, EYA4, CARD11, EPHA8, AKT1S1, EPS8, ING5, BTBD10, RPAIN, EREG, ZDHHC18, USP48, KAT8, ESRRA, PCBD2, USP44, MAGT1, REG4, RASSF4, RAB34, FSD1L, KLF16, FERMT3, JAM3, FBXL18, NAA25, WWC2, RHPN1-AS1, FSD1, BRCC3, FECH, DERL1, CHAC1, TRPM8, AHNAK, GGCT, LINC01260, CUEDC2, DUSP26, BHLHE41, WNK2, FGF4, RTN4R, NBEAL1, CDK15, NDRG4, NT5DC2, BCL11B, NIBAN2, FGF7, IRX1, FDXR, C10orf88, LIN28A, BPTF, FAP, FBP1, GGNBP2, LINC00115, CAMKMT, FCER1A, FCGR1A, GEMIN7, ADGB, SUV39H2, NKAP, RIOX1, CENPU, DYNC2H1, MCPH1, TNFAIP8L2, RNASEH2B, HMBOX1, TCTN1, CHPF, FCGR1B, DIAPH1, CXCL11, DES, MIR300, ANPEP, MIR766, MIR769, MIR767, MIR671, SNHG9, APAF1, LOC730100, NBAT1, BIRC3, NAIPP2, USP17L30, USP17L29, USP17L28, USP17L27, USP17L26, USP17L25, USP17L24, APLP2, LOC728196, LINC00460, MIR663A, APOC2, ANG, AMPD1, AIF1, MIR744, MIR1468, TMEM238L, CASC11, PCED1B-AS1, TPT1-AS1, MFT2, MIR1224, ALAD, HOXA-AS3, RAB6C-AS1, AGAP2-AS1, UBE2CP3, MATN1-AS1, C20orf181, FAM83H-AS1, EGOT, MIR760, MIR543, MIR708, ALDH1A1, AKR1B1, MIR301B, MIR873, MIR656, MIR654, H2AC19, MIG7, ARL2, H3P38, ARL3, ARNTL, SCFV, RAET1K, ART1, ASCL1, MNX1-AS1, RASSF10, MT1IP, FLVCR1-DT, CERNA2, ATIC, POTEM, MIR455, MIR486-1, MIR484, MIR483, LINC00589, ATP1A3, ZFAT-AS1, MIR509-1, MIR487B, MIR542, MIR411, MIR610, APOE, APP, MIR646, AR, ABCC6, MIR630, MIR628, MIR625, MIR616, ARCN1, MIR608, ARHGDIA, MIR605, MIR603, ARL4D, MIR596, MIR593, MIR577, MIR576, MIR564, MIR548C, MIR532, MIR1265, MIR1287, MIR506, LINC01857, MIR6807, MIR6852, MIR6743, MIR6165, LNCNEF, UBE2R2-AS1, LINC01198, ACVR1B, TRPM2-AS, LINC01494, CASC9, ACYP2, LSINCT5, FOXD3-AS1, ADA, LINC-ROR, HOXC13-AS, HOXC-AS2, HOXA10-AS, MIR5582, PCAT1, LINC01023, ADAM10, GATD3B, TP53COR1, MIR1249, CCND2-AS1, H3P29, AAVS1, ABCA1, H3P24, ABCA4, H3P8, H3P9, LNCRNA-ATB, MNS16A, ACP3, PSMD6-AS1, CNE-2, H3P14, ACTC1, MIR3142HG, ACTG1, MDC1-AS1, CST12P, FOXD1-AS1, ACTG2, LINC02210-CRHR1, ACTN4, SNHG14, MIR4725, ERVK-20, MIR4518, MIR4775, MIR210HG, LINC01503, LUCAT1, LINC00645, MAGI2-AS3, CARD8-AS1, MIR3908, LINC00673, MIR4262, MIR3175, MIR4295, MIR3148, MIR2276, FTX, MIR1290, ADSL, MIR1202, AP2A1, MIR1271, MIR1825, AGER, MIR1205, APLNR, ADORA2A, ADORA1, LINC01426, LOC100507703, MIR4493, MIR1587, MIR4500, MIR499B, MIR4731, ADAR, RAB4B-EGLN2, BCL2L2-PABPN1, ADARB2, RBM14-RBM4, PSMB8-AS1, CBR3-AS1, ADCY2, ADCY8, ADAMTS9-AS2, MELTF-AS1, ADCYAP1, TUNAR, PWAR6, HOXD-AS2, ADK, PXN-AS1, MIR508, ATP7A, RICTOR, CYC1, MIR100, MIRLET7G, MIRLET7E, MIRLET7C, CYP1B1, CYP2C9, WDFY3-AS2, HAPLN4, FAM224A, GASAL1, CASC15, HAGLR, LINC00909, LINC00511, CYP2D6, USP17L9P, SLC39A4, FEZF1, CYP2E1, TRABD2B, HES5, KMT5A, LINC00320, CYLD, CTSK, CLK1, CTNND2, CNTF, MIR181B1, CNTN1, COL4A1, COL9A1, COL9A2, COL9A3, MIR154, COMP, COX4I1, COX5B, COX7A2, ATF2, CRH, CRHR1, CRMP1, CRY1, CRY2, CSPG4, CST3, MIR128-1, CTBP2, CTNND1, CYP2J2, CYP4B1, USP17L2, LHFPL3, LINC00319, ZNF326, RSPO1, EMC10, CXCL17, GADD45A, DDIT3, H19, LINC00515, HCA1, DDX6, CYP4X1, ASPM, SGMS1, SVIP, SHPRH, DHX15, PTF1A, SYT14, MCOLN2, TAC4, ZDHHC23, CADM2, STPG4, TUSC7, SLC9A9, DBP, ASPG, CYP27B1, DAG1, PRAC2, DAO, SKA2, SOX2-OT, DAXX, ACTBL2, DBN1, DCC, DCK, RAB43, GPIHBP1, CHSY3, CELIAC2, TRIM59, LIN9, FAM133A, PAXX, SCAI, DLX6-AS1, CCR7, MIR190A, MIR503, BTG1, C1QBP, SAMD12-AS1, SERPING1, DUXAP8, RGMB-AS1, MIR425, PTTG1IP, MIR422A, CA11, MIR379, CALCA, CISD2, MIR196B, CALML3, MIR370, MIR376C, CAMK2G, CAMP, CAPNS1, CASP2, CASP6, MIR330, CBL, BUB1, H4C15, CLIC1, MIR362, MIR501, MIR499A, MIR527, MIR520D, MIR519D, MIR517A, BAG1, MIR520C, MIR520B, MIR520A, ADGRB1, BCAT1, MIR496, BCL2L2, MIR432, MIR202, BDH1, CEACAM1, MIR488, PRDM1, BMPR2, MIR409, ZFP36L1, KRIT1, MIR323A, MIR302C, MIR302B, CDK5, MIR218-2, MIR217, CDK8, MIR212, CDKN2D, CDKN3, CDX2, CEBPA, CEBPD, CHD1, CHD4, CHEK1, CHKA, CISH, CLC, MIR19B1, CLCN4, MIR199A2, MIR199A1, MIR197, MIR196A2, CLCN7, CDH18, CDH11, CDH5, CD28, CCND3, CCNF, LOC441204, POTEKP, MIAT, TNFSF12-TNFSF13, CD247, CD8A, MIR34B, CD27, TNFSF8, CDH4, ENTPD1, CD47, MIR302A, CD48, MIR29C, MIR29B2, MIR29B1, CD74, MIR28, CDC25B, DEPDC1, GUCY1B1, TENT5A, P2RX4, EIF3D, EIF3C, EIF3A, PDE5A, NCOA1, OPRD1, KLF7, PLA2G4C, CASK, OPRK1, OXCT1, CDK10, TAGLN2, P2RY1, FURIN, PCSK6, GPR65, SMARCA5, CUL1, DYRK2, RAD54L, CAVIN2, PAH, SNHG3, EIF3I, VAMP8, TNFRSF11B, OPCML, NFATC3, NFATC4, CFLAR, NFIB, NFIL3, NFIX, CES2, NHS, SUCLG1, NINJ2, NOP2, NPY, DLK1, RIOK3, NOVA2, TNFRSF6B, RIPK2, NPM1, NPPC, NTF3, NTS, ODC1, HYAL2, SERPINB2, SPOP, PER3, TAM, PRKN, BAP1, PAWR, H4C9, TKTL1, SMC1A, USP9X, PCBD1, DVL1P1, BAS, GATD3A, CDR3, SPARCL1, PCSK1, ANP32A, PWAR5, CDK2AP1, CDK16, PDE4C, KMT2D, PDK3, CSRP3, MLLT10, PSCA, CDC45, FZD4, PAM, H2AC18, MAD1L1, HYAL3, H4C14, H4C13, H4C5, H4C2, H4C8, H4C3, H4C11, H4C12, H4C6, H4C4, H4C1, PAK1, H3C10, H3C12, H3C8, H3C11, H3C6, H3C3, H3C4, H3C1, H2AC20, APLN, NEO1, ENOSF1, FHL5, MOV10, GOSR1, LITAF, GAL3ST1, ADAMTS1, MAGED1, MPG, MAPK8IP1, ROCK2, MPI, ARHGEF6, AIM2, NRXN3, GSTO1, MPZ, NCR1, MRE11, MYO1B, ZNF264, DDX23, ZRANB2, RECQL4, TSIX, MSR1, BAG3, MMP16, MMP15, BCAR1, CD99, SPOCK2, CKAP5, PCLAF, MITF, KMT2B, SLK, MME, DCAF1, NOS1AP, HERPUD1, ULK2, UBE3C, KDM4A, PHF14, MDC1, SH3PXD2A, AKAP12, WTAP, APOBEC3B, SOX13, BABAM2, MMP13, ADIPOQ, MST1, SEPTIN2, MYBL2, MMUT, DNAJA3, MUTYH, ANGPTL1, SYT7, MVD, PRC1, MX1, SOCS3, MAP3K14, HAP1, PLOD3, MT1A, WASL, H3C7, BTRC, MBD4, TIMELESS, CCNA1, MTMR3, MYH10, MYL2, NAP1L1, NCF2, TRIM37, SLC16A4, SLC16A3, PDLIM1, B4GALT5, MT1B, NREP, ASIC3, S1PR2, MT1F, GPR37L1, MT1G, STK17A, AIMP1, NUMBL, MT1H, NOG, MT1M, MT1L, MT1X, SLC16A7, ARHGEF2, OSMR, COX1, EBAG9, MTNR1A, CCNB2, TUSC3, PDK4, NTT, SPOCK1, ST13, ST2, RBBP5, RBBP6, RBP1, SSRP1, ITPRID2, SREBF2, SRI, SRD5A1, SRC, SPI1, RNASE3, SP3, REN, DPF2, SOX5, REV3L, SOX1, SOS1, RGS3, SOD2, RGS4, RMRP, ST14, STAR, KDM5A, STAT2, VPS72, RAB2A, RAB3A, RAB3B, RAB6A, TBX1, RAC2, TAP1, TAL1, TACR1, RAC3, RAD51B, MOK, RAD52, VAMP7, RANGAP1, SULT1A1, RAP1B, STK4, STIM1, RAP2B, PLAAT4, RASA1, SNRNP70, RNF5, TFEB, TRA2B, SORT1, ST8SIA1, S100A11, SIAH1, SHOX2, S100A13, SAA4, SHBG, SH3GL3, TSPAN31, SGK1, SRSF3, ABCE1, SRSF1, SFRP4, SFRP2, SCN8A, MAP2K4, SEL1L, SDHD, SDHC, SCNN1D, CCL18, CX3CL1, RYR3, SIX3, SKI, RYK, SMPD1, RORA, RORB, SMARCB1, RPA3, SMARCA2, RPL11, RPL34, SLIT1, RPS6, SLC18A1, RPS6KA1, SLC9A5, RPS6KA3, RPS6KB1, RPS15, RRM1, SLC2A5, SLC2A3, RRM2, SLC1A3, SLC1A2, SLAMF1, PRDX2, TEAD1, PTPRJ, VCAM1, VTN, VSNL1, VRK1, VIP, PLP1, PLTP, PMP22, PMS1, PNLIP, VDAC2, VCL, VASP, TERF1, UTRN, POLB, USF1, UQCRC2, POMC, PON1, UGP2, POR, UCHL1, SUMO1, POU3F3, PLEK, WEE1, PLD2, WNT2, NELFE, PF4, PFN1, DAP3, DNALI1, PRDM2, ZYX, ZNF217, RNF112, ABCB4, ZNF143, PHB, PHEX, PIK3C2B, PKD1, PKP2, PLA2G5, PLAT, WRN, WNT2B, WNT11, PLCL1, PLCG1, UBE2I, U2AF1, TXNRD1, MAP2K2, PRL, TNFAIP2, PROP1, TMSB4X, TM7SF2, TSPAN8, LGMN, PRSS8, TKT, NKX2-1, TIMP3, KLK6, PSD, PSMB8, PSMD10, PTCH1, PTH, PTGS1, TFF3, PTPN9, PTPRA, PTPRC, PTPRF, MAP2K3, TP53BP1, MED1, TPD52, TNFSF4, PTPA, TTR, TTK, PPP5C, TSC2, PREP, TRPC5, SRGN, PRKACG, PRKCD, PRKCE, TRAF3, TRAF2, TRAF1, HSP90B1, NR2C2, CRISP2, PRKG2, MAPK7, TPM1, TPI1, TPD52L2, ARHGEF11, TRIM14, CIITA, UBE2S, CPS1-IT1, HIPK2, HOXA7, MRPL42, LAMTOR2, TRIB2, HOXA10, POLM, SGSM3, HOXA11, POLL, EIF3K, ZBTB32, BHLHE22, HOXA13, HOXB1, GLS2, HOXB7, INTU, HOXB9, EIF2AK1, HOXC4, HOXC8, LAT, HOXA5, LINC00339, NXT1, SAP30BP, MBL3P, HNRNPA1, HNRNPC, NOX4, HNRNPF, STOML2, EHD3, HNRNPK, ERVW-1, BICRA, HNRNPU, A1CF, RMC1, HOOK2, HOXA3, TRA2A, MYLPF, REPIN1, CARD10, TMOD4, UHRF1, HOXA4, BRD7, NOX1, MLH3, IL1RN, CLEC5A, QPCT, RASGRP3, POTEH, HTR1E, HTR2C, RAB38, HTR5A, HTR6, HYAL1, ID1, DAPK2, AMACR, HBP1, PATZ1, WBP2, PSD4, ID4, ZNF281, KCTD2, DAAM2, TNFRSF13B, IGFBP4, TRAM1, IGSF1, BAMBI, PRDX5, BRMS1, PRKD2, RANBP6, SNORD47, CKAP2, HOXD4, HOXD10, FBXO8, HPR, HRC, SERBP1, PRPF31, HRG, PRMT1, DNM3, CNTNAP2, KANK2, RWDD3, SYF2, CLIC4, ZDHHC5, HTR1A, LETMD1, MPC2, RPL36, PCA3, HNF4A, TRAT1, SAMD9, PINX1, SDHAF2, CMTM6, FOCAD, MKS1, ELOVL2, CASZ1, BCOR, EPS8L1, PGPEP1, ANKRD49, DYM, STMN3, ARHGAP35, TRIM44, IL17RD, GRM8, CXCL1, DDIT4, PDIA3, RIN2, TREM2, NANS, DCUN1D1, MCUB, PID1, GPX4, EPN3, GLUL, ASIC4, SAGE1, GNRHR, GPC1, HES6, GPD1, LGR4, STYK1, LAPTM4B, GPD2, GPI, CCR10, IMP3, STEAP3, APPL2, GRK5, GRK6, HEATR1, PIWIL2, AGGF1, ANO1, TMEM45A, GSTM2, GUCY1A1, XCL1, PHF21A, TLR7, GOLM1, NT5C3A, HLA-F, NUSAP1, CPA4, HERC5, PLEKHO1, HLA-G, HMGB2, HMGCR, IRAK4, GOLGA7, RMDN1, SH3GLB1, ADIPOR1, GAL, HMGA1, PLEKHA8P1, UBXN1, FIS1, TMED5, FOXA2, SLC22A17, TAOK3, TPCN1, HLA-DQA1, SHC3, IL17D, GALNT7, HDAC2, CMPK1, HEXA, RAB23, HEXB, TPPP3, GINS2, STYXL1, RASD1, PPIL1, SF3B6, KLF13, IL23A, HIVEP2, SIRT7, ISYNA1, POLK, HLA-DMA, CRLF3, ANGPT4, SLC44A1, NOMO1, MGAT5, C1D, SEMA4B, STK25, VAT1, HOXB13, SLC30A9, MERTK, LSS, MAD2L2, GPNMB, HAX1, LUM, IFI30, SMAD6, RBM14, LYN, LYZ, TACSTD2, CPQ, PIAS3, MAD2L1, SMAD1, TUBB3, IRF9, KLF2, LOXL2, LMO2, LLGL1, RNASEH2A, LAMC1, CELF2, CELF1, LBP, LCK, IGF2BP2, LDLR, LEP, NPRL2, RAD51AP1, LEPR, TXNIP, LIG1, PDLIM5, LIM2, SMC2, CCT4, MRPL28, SLC34A2, SLC35A1, SPTLC1, HTATIP2, LIMS1, HMG20B, CCNO, ZFPM2, RAB8A, ABCC5, SAE1, MCM7, CHAF1A, ME1, MEF2C, ZBTB33, MEFV, MAP3K1, HNRNPDL, TNFSF15, USP15, DLEU1, WDR1, P2RY14, MRC2, MEOX2, UBAP2L, SNAP91, TOX4, TLK1, SEC24D, MELTF, MGAT1, MCM6, DNM1L, MCM3, PPIF, APC2, CDK2AP2, ABCC4, MAG, SPRY1, TRIB1, MAGEA2, MAGEA6, MAOA, TNK2, WASF2, ATP6AP2, MAP1B, CEBPZ, MAS1, MBD1, BCAP31, OPTN, MBL2, ARL4A, MBP, MCAM, RAD50, EBP, LAMB2, CCT8, ITGB5, ATF6, CD93, ITGA4, ITGAX, FNDC3A, CILK1, CPEB3, PHLDA1, COPG1, ITGB4, OIP5, TUSC2, USP39, PDAP1, ACOT7, VSIG4, ITGB6, ITGB8, TREX1, TP53TG1, ITIH4, ITK, PTENP1, ITPKA, RAB18, ITGA2B, ELL2, RAB21, IL5, COTL1, IL6ST, CXCR2, NEDD4L, ICOSLG, PHLPP1, ARC, PLCB1, JMJD6, ACSBG1, FOXK2, LARP4B, ILF2, ING2, TOGARAM1, IQSEC2, KIF1B, ZNF423, INS, PDXDC1, MYT1L, IRF1, JAK1, JARID2, JUN, KCNQ1OT1, STIP1, KCNMB1, KHK, BRD8, MALT1, RAB10, KIF5B, PGRMC1, KLK2, KLC1, KPNB1, KPNA2, KRT1, LAMA4, TRAF3IP2, GIPC1, CHL1, LAMA5, PLK4, TCFL5, NFAT5, CERS1, LAMB1, CKAP4, COPS5, FSTL1, METAP2, SOX21, CD82, HHLA2, PTPRT, RPP14, ADAMTS5, ADAMTS8, ESM1, TRIOBP, TPPP, KCNA3, RAPGEF4, WWP2, WWP1, TENT4A, KCNA10, DSTN, KCNB1, KCNH1, KIF2C, SLC27A2, KCNK1, SLC38A3, SEMA7A

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A number sign (#) is used with this entry because glioma may present as part of a tumor predisposition syndrome caused by mutation in the PTEN gene (601728) on chromosome 10q23.

For a general phenotypic description and a discussion of genetic heterogeneity of glioma, see GLM1 (137800).

Clinical Features

Staal et al. (2002) identified a heterozygous germline mutation in the PTEN gene in a patient with glioma. A 38-year-old male presented with focal seizures of the right arm and dysphasia. No neurologic abnormalities were found on examination. Antiepileptic drug medication resulted in a marked reduction of the seizures. Several years later a CT brain scan was made because of progressive headaches and memory difficulties. A right frontal meningioma was detected, removed, and pathologically confirmed, with no signs of malignancy. Five years later the seizures had spread to the patient's right leg. A CT scan suggested a low-grade glioma in the left frontal lobe, for which the patient later underwent surgery. Histologic examination revealed tumor cells with perinuclear unstained cytoplasm, with irregular round to oval nuclei, with some mitotic activity. The capillary network in the tumor was unremarkable and there was no necrosis. This tumor was classified as an anaplastic oligodendroglioma. The patient underwent radiotherapy. Several years later the patient suffered a decline of cognitive functioning. CT brain scan showed regrowth of the left frontal tumor, which was again treated surgically. Histologic examination revealed a similar profile to that of the former tumor, but with more pleiomorphism of the nuclei of the tumor cells, more mitotic activity, microvascular proliferation, and small areas of necrosis. The diagnosis was anaplastic oligodendroglioma with signs of ongoing dedifferentiation. He was treated with chemotherapy for residual tumor, but after nearly a year there was further tumor growth.

Molecular Genetics

In a patient with glioma and meningioma, Staal et al. (2002) detected a heterozygous arg234-to-gln (R234Q) mutation in exon 7 of the PTEN gene (601728.0029). The mutation was found in DNA obtained from peripheral blood, the meningioma, and the 2 oligodendrogliomas of the patient, and was not found in 80 control chromosomes. No LOH was detected in tumor-derived DNA samples. In cell proliferation analyses, mutant cells proliferated at a roughly 5-fold higher rate than cells transfected with wildtype PTEN over a 2-week period. Transfection assays showed that while wildtype PTEN induced apoptosis, the R234Q mutant did not.