Craniodiaphyseal Dysplasia Watchlist (log in to enable) Retrieved 2021-01-23 Source Orphanet Trials — Genes SOST, CDKL5, CDA, GRIA2, CXCL8, NPPA, CLIP1 Drugs — Interested in hearing about new therapies? Registered! Craniodiaphyseal dysplasia is a rare sclerotic bone disorder with a variable phenotypic expression with massive generalized hyperostosis and sclerosis, particularly of the skull and facial bones, that may lead to severe deformity.