Hypogonadism, Male, With Mental Retardation And Skeletal Anomalies

Sohval and Soffer (1953) described 2 brothers who were identically affected with mental retardation, multiple skeletal anomalies, and hypogonadism. The testicular histopathology was distinctive. All the seminiferous tubules were involved by one of two distinct processes: true germinal aplasia or complete fibrosis, with no gradations between them. Both brothers had fasting hyperglycemia and glucose intolerance. Skeletal anomalies were restricted to the cervical spine and superior ribs.