Intussusception

The jejunal polyps of Peutz-Jeghers syndrome (175200) lead to intussusception. Idiopathic intussusception shows a modest degree of familial aggregation; see review of Jolly et al. (1982), who reported a family in which 5 members in 3 generations had intussusception in infancy. A girl without intussusception developed malignant hyperthermia of a nonrigid type (145600). Her father and a sister had elevated levels of serum creatine kinase. Two older sibs died inexplicably following anesthesia for intussusception surgery and may have had malignant hyperthermia. Jolly et al. (1982) considered the coexistence of these 2 disorders in this family to be happenstance, although clearly each was hereditary.