Focal Epithelial Hyperplasia, Oral

Description

Focal epithelial hyperplasia is a benign hyperplasia of the oral mucosa induced by human papillomavirus (HPV) (Premoli-De-Percoco et al., 1993).

Clinical Features

Premoli-De-Percoco et al. (1993) demonstrated a familial aggregation of oral FEH in a Venezuelan family. DNA sequences of HPV were demonstrated in the affected individuals. HPV13 and HPV32 have been demonstrated as etiologic agents; HPV13 was demonstrated in this kindred. (See 226400 and 305350 for possible examples of skin disorders (epidermodysplasia verruciformis) due to genetic susceptibility to HPV.)

In 2 of 4 sibs born of Mexican-American parents of Navajo and Comanche Native American lineage, Mealey et al. (1993) described FEH in association with leukocyte adhesion deficiency (116920).

Population Genetics

Oral focal epithelial hyperplasia is found predominantly in Eskimos and American Indians (Archard et al., 1965; Gomez et al., 1969).

Inheritance

The transmission pattern of focal epithelial hyperplasia in the family reported by Premoli-De-Percoco et al. (1993) was consistent with autosomal recessive inheritance.